Friedmann / Giannelli Advances in Genetics

1. Auflage 1999
ISBN: 978-0-08-052232-6
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, Band Volume 41, 206 Seiten

Reihe: Advances in Genetics

Advances in Genetics has established itself as an outstanding vehicle for the dissemination of research results in genetics. Once again, authoritative papers are presented here, beginning with a review by Rai and Black highlighting the salient features of mosquito genomes and their evolution. The recent progress which has been made by the cloning and characterization of two cooperating partners of the Neurospora blue light signal transduction chain is presented by Linden, Balario, Arpaia, and Macino. The emergence of the concept of X-linked mental retardation (XLMR) is discussed by Neri and Chiurazzi, as well as epidemiologic data and XLMR gene updates. In chapter 4, Mahato, Smith, and Rolland provide insights into the potentials of plasmid-based gene therapy and critical evaluation of gene delivery sciences and clinical applications of gene medicines. Kathleen Triman completes the volume with an outline of the genetic strategies designed to improve our understanding of the structure and function of 23S ribosomal RNA in E. coli.

Autoren/Hrsg.

Friedmann, Theodore

Giannelli, Francesco

Inhaltsverzeichnis

1;Cover;1
2;Advances in Genetics;4
3;Copyright Page;5
4;Contents;6
5;Contributors;8
6;Chapter 1. Mosquito Genomes: Structure, Organization, and Evolution;9
6.1;I Overview;9
6.2;II Mosquito Taxonomy, Evolution, and the Fossil Record;10
6.3;III Cladistic Analysis of Culicidae;11
6.4;IV Chromosome Number Is Conserved in Culicidae;13
6.5;V Sex Chromosome Evolution in Culicidae;15
6.6;VI Genome Size and General Genome Organization;15
6.7;VII Heterochromatin: Localization, Variation, and Expression;25
6.8;VIII Saturated Linkage Maps Generated through Multipoint Mapping;31
6.9;IX Summary;34
6.10;References;35
7;Chapter 2. Seeing the Light: News in Neurospora Blue Light Signal Transduction;43
7.1;I Introduction;44
7.2;II The Perception of Light in Neurospora;45
7.3;III The Interplay of Blue Light and Other Regulatory Pathways in Neurospora;49
7.4;IV Mutational Analysis of Blue Light Signal Transduction in Neurospora;50
7.5;V The Neurospora Blue Light Regulatory Proteins WC-1 and WC-2;52
7.6;VI Concluding Remarks;58
7.7;References;59
8;Chapter 3. X-Linked Mental Retardation;63
8.1;I Introduction;64
8.2;II Syndromal XLMR;65
8.3;III Nonsyndromal XLMR (MRX);88
8.4;IV Conclusion;91
8.5;References;91
9;Chapter 4. Pharmaceutical Perspectives of Nonviral Gene Therapy;103
9.1;I Why a Gene-Based Approach for Protein Therapy?;105
9.2;II Commercialization of Gene Therapy Products;108
9.3;III Basic Components of Gene Expression Plasmids;112
9.4;IV Gene Delivery Systems;118
9.5;V Formulation Factors Influencing Gene Transfer;131
9.6;VI Biodistribution and Pharmacokinetics of Plasmids;132
9.7;VII Intracellular Trafficking of Gene Medicines;138
9.8;VIII Biological Opportunities for Gene Therapy;142
9.9;IX Concluding Remarks;151
9.10;References;152
10;Chapter 5. Mutational Analysis of 23S Ribosomal RNA Structure and Function In Escherichia coli;165
10.1;I Introduction;165
10.2;II Methods of Detection of rRNA Mutants in Escherichia coli;166
10.3;III Mutational Analysis of 23S rRNA Structure and Function;170
10.4;IV Conclusions;177
10.5;References;195
11;Index;205