In silico protein design

Erscheinungsjahr 2014
ISBN: 978-1-907568-26-8
Verlag: Woodhead Publishing

Buch, Englisch, Band 59, 300 Seiten

Reihe: Woodhead Publishing Series in Biomedicine

In silico protein design covers the computational techniques that are most frequently utilized by protein engineers. The advent of biotechnology has made proteins play an increasingly important role as medicinal therapeutics, catalysts in the chemical process industries, and numerous other applications. Many of these applications are dependent on the field of protein engineering to either modify existing proteins to alter/enhance their functionality or to create novel proteins capable of novel functionality. In the last decade, the rapid advances made by the computer industry have allowed for the creation of computer systems capable of modelling proteins to become relatively commonplace. As such, there has been a marked increase in the use of computational methods to engineer proteins.

Autoren/Hrsg.

Frenz, C M

Fachgebiete

• Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik
• Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie

Inhaltsverzeichnis

Part 1 Fundamentals: Introduction to proteins; Introduction to computer modelling; Protein structure prediction. Part 2 Modifying existing proteins: Modifying stability; Modifying activity; Altering protein pH profiles - pKa prediction; altering protein pKa's. Part 3 Design of novel proteins: Engineering novel proteins.

Über Autor(innen)

Christopher M. Frenz is a faculty member in the Department of Computer Engineering Technology at The New York City College of Technology (CUNY). He is the author of the books Pro Perl Parsing (Apress) and Visual Basic and Visual Basic.NET for Scientists and Engineers (Apress) and has 42 published articles. Christopher Frenz has an extensive research interest in the application of computational methods to the study of protein structure and function.