Neuronal Network Dynamics in 2D and 3D in vitro Neuroengineered Systems

Softcover Nachdruck of the original 1. Auflage 2016
ISBN: 978-3-319-80758-4
Verlag: Springer International Publishing

Buch, Englisch, 148 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 2584 g

Reihe: Springer Theses

The book presents a new, powerful model of neuronal networks, consisting of a three-dimensional neuronal culture in which 3D neuronal networks are coupled to micro-electrode-arrays (MEAs). It discusses the main advantages of the three-dimensional system compared to its two-dimensional counterpart, and shows that the network dynamics, recorded during both spontaneous and stimulated activity, differs between the two models, with the 3D system being better able to emulate the in vivo behaviour of neural networks. The book offers an extensive analysis of the system, from the theoretical background, to its design and applications in neuro-pharmacological studies. Moreover, it includes a concise yet comprehensive introduction to both 2D and 3D neuronal networks coupled to MEAs, and discusses the advantages, limitations and challenges of their applications as cellular and tissue-like in vitro experimental model systems.

Zielgruppe

Research

Autoren/Hrsg.

Frega, Monica

Fachgebiete

• Mathematik | Informatik EDV | Informatik Informatik Künstliche Intelligenz Neuronale Netzwerke
• Technische Wissenschaften Elektronik | Nachrichtentechnik Elektronik
• Naturwissenschaften Biowissenschaften Zellbiologie
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Biotechnologie: Mikrotechnologie, Nanobiotechnologie
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft

Inhaltsverzeichnis

Introduction.- Dissociated Neuronal Networks Coupled to Micro-Electrode Arrays Devices.- In Vitro Neuronal Networks.- 3D Neuronal Networks: State of the Art.- 3D Neuronal Networks Coupled to MEAs.- Neuro-pharmacological Studies.- Discussion and Conclusion.- Data Analysis.