Fleckenstein / Breemen / Groß Cardiovascular Effects of Dihydropyridine-Type Calcium Antagonists and Agonists

Erscheinungsjahr 2013
ISBN: 978-3-642-70499-4
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 9, 511 Seiten, eBook

Reihe: Bayer-Symposium

Zielgruppe

Research

Autoren/Hrsg.

Fleckenstein, A.

Breemen, C. Van

Groß, R.

Hoffmeister, F.

Inhaltsverzeichnis

Welcome.- Calcium Antagonists and Calcium Agonists: Fundamental Criteria and Classification.- With 18 Figures and 5 Tables.- Session I: Ca-Channels.- Mechanism of Calcium Channel Modulation by Dihydropyridine Agonists and Antagonists.- Ca Entry into Vascular Smooth Muscle.- Calcium Currents in Mammalian Central Neurones.- Session II: Molecular Interactions.- Chemistry of Dihydropyridines.- Structure-Function Relationships of 1,4-Dihydropyridines: Ligand and Receptor Perspectives.- Calcium Channels: Introduction into Their Molecular Pharmacology.- The Dihydropyridine Receptors.- A Proposed Pharmacological Role for Dihydropyridine Binding Sites in Heart and Coronary Smooth Muscle.- Session III: Myocardial Effects.- The Effects of 1,4-Dihydropyridine Type Ca2+-Channel Antagonists and Agonists on Intracellular [Ca2+] Transients Accompanying Twitch Contraction of Heart Muscle.- Voltage-Dependent Modulation of Cardiac Ca-Channels by Dihydropyridines.- Effects of the Calcium Agonistic Dihydropyridine Bay K 8644 on the Heart.- Myocardial Effects of Dihydropyridines in Patients.- Session IV: Effects on Smooth Muscle.- Effect of Dihydropyridines on Visceral Smooth Muscle.- Effects of Ca2+ Antagonists on Isolated Rabbit Mesenteric Resistance Vessels as Compared to Rabbit Aorta.- Effect of Dihydropyridine Calcium Channel Modulators on Isolated Peripheral and Cerebral Vessels.- Effects of Ca+ +-Agonistic and Ca+ +-Antagonistic 1,4-Dihydropyridine Compounds on Tonic and Phasic Activation of Extramural Coronary Vasculature.- Effects of Dihydropyridines on Human and Animal Isolated Vessels.- Endothelium-Dependent Vascular Relaxation.- Session V: Circulation.- Coronary and Systemic Hemodynamic Effects of Dihydropyridines.- Effect of a Dihydropyridine-Type Calcium Antagonist on CerebralBlood Flow and Metabolism.- Calcium, Dihydropyridines and Resistance Vessel Tone.- Differences Between Dihydropyridine and Non-Dihydropyridine Calcium Antagonists in Inotropic, Chronotropic, Dromotropic and Vascular Effects: Differences in Underlying Mechanism.- Effects of Calcium Antagonists on Fixed and Dynamic Obstructions in Patients with Severe Coronary Artery Disease.- Session VI: Hypertension.- Effects of Calcium Antagonistic and Agonistic Dihydropyridines on Experimental Hypertension and Vascular Damage.- On the Antihypertensive Properties of Nitrendipine, with Observations of Its Effects on Electrolyte Excretion.- The Use of Calcium Antagonists in the Treatment of Arterial Hypertension.- Calcium Antagonists for Identification of Mechanisms and Treatment in Patients with Essential Hypertension.- Session VII: Tissue Protection.- Dihydropyridines and the Protection of the Ischaemic and Anoxic Myocardium.- Protection Against Complete Cerebral Ischemia by Nimodipine.- Interdependence of Antihypertensive, Anticalcinotic, and Antiarteriosclerotic Effects of Calcium Antagonists — Model Experiments on Spontaneously Hypertensive Rats (SHR).