Fisher Biochemical Pharmacology of Blood and Bloodforming Organs

Erscheinungsjahr 2012
ISBN: 978-3-642-75865-2
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 101, 587 Seiten, eBook

Reihe: Handbook of Experimental Pharmacology

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Fisher, James W.

Weitere Mitwirkende

Agrawal, K.

Beckman, B.S.

Capizzi, R.L.

Dugdale, M.

Eaves, A.C.

Eaves, C.J.

Fisher, J.W.

FitzGerald, G.A.

Joyce, R.A.

Kerins, D.M.

Lange, R.D.

Mason-Garcia, M.

McDonald, T.P.

Mills, D.C.B.

Nakashima, J.

Quesenberry, P.J.

Smith, J.B.

Solomon, L.R.

Spivak, J.L.

Inhaltsverzeichnis

1 Introduction.- 2 Fundamental Control of Hematopoiesis.- A. Introduction.- B. Hierarchical Organization of Hematopoietic Cells.- C. Assay and Characterization of In Vitro Clonogenic Cells.- D. Use of In Vitro Clonogenic Cell Assays.- E. Newer Assays for More Primitive Cells.- F. Regulatory Mechanisms.- G. Future Outlook.- References.- 3 Kidney Regulation of Erythropoietin Production.- A. Introduction.- B. Model for the Control of Erythropoietin Production.- C. Hypoxia and Erythropoietin Production.- D. Adenosine and Erythropoietin Production.- References.- 4 The Mechanism of Action of Erythropoietin: Erythroid Cell Response.- A. Introduction.- B. Model Systems for Studying the Interaction of Erythropoietin with Erythroid Progenitor Cells.- C. Interaction of Other Growth and Development Factors with Erythroid Progenitor Cells.- D. The Erythroid Differentiation Program.- E. Signal Transduction in Erythroid Progenitor Cells.- F. Erythropoietin as a Competence or Progression Factor.- G. Conclusion.- References.- 5 The Arachidonic Acid Cascade and Erythropoiesis.- A. Introduction.- B. Evidence for the Roles of Arachidonic Acid Metabolism in Erythropoiesis.- C. Future Directions for Research.- References.- 6 Iron Deficiency and Megaloblastic Anemias.- A. Iron-Deficiency Anemia.- B. Megaloblastic Anemias.- References.- 7 Erythropoietin in the Anemia of End-Stage Renal Disease.- A. Assay of Erythropoietin.- B. Pathogenesis of the Anemia of Chronic Renal Failure.- C. Kidney Production of Erythropoietin.- D. Erythropoietin in Therapy of Renal Anemia.- E. Conclusions.- References.- 8 Humoral Control of Thrombocytopoiesis.- A. Introduction.- B. Model for Megakaryocytopoiesis.- C. Controlling Factors.- D. Other Factors Affecting Thrombocytopoiesis.- E. Clinical Aspects of Thrombopoietin.- F. Future of Thrombopoietin.- References.- 9 Arachidonic Acid Metabolism Platelets and Thromboembolic Disease.- A. Arachidonic Acid Metabolism.- B. Thromboembolic Disease.- C. Concluding Comments.- References.- 10 Chemical Agents That Inhibit Platelet Aggregation.- A. Introduction.- B. Platelet Physiology.- C. Platelet Structure.- D. Platelet Involvement in Thrombosis.- E. Platelet Responses.- F. Inhibition of Platelet Aggregation.- G. Conclusions.- References.- 11 Anticoagulants, Antithrombotic and Thrombolytic Agents.- A. Anticoagulants.- B. Thrombolytic Therapy.- C. Antithrombotic Therapy.- References.- 12 Granulocyte-Macrophage Growth Factors.- A. Introduction.- B. Historical Background.- C. Growth Factors.- D. Other Interleukins.- E. Inhibitors.- F. Cellular Production and Networking.- G. Microenvironment.- H. Conclusions.- References.- 13 Chemical Agents Which Suppress Myelopoiesis: Agranulocytosis and Leukemia.- A. Introduction.- B. Normal Marrow Cell Kinetics.- C. Pathophysiologic Mechanisms for Drug-Induced Neutropenia.- D. Neutropenia Associated with Cytotoxic Chemotherapeutic Agents.- E. Drug-Induced Myeloid Suppression.- F. Idiosyncratic Neutropenias.- G. Pseudoneutropenia.- H. Secondary Leukemia.- J. Conclusions.- References.- 14 Drugs Useful in the Chemotherapy of the Acute Leukemias.- A. Introduction.- B. Antimetabolites.- C. Drugs that Intercalate in DNA.- D. Podophyllotoxin Derivatives.- E. Vinca Alkaloids.- F. Alkylating/DNA Binding Agents.- G. Adrenal Glucocorticoids.- H. Enzymes.- J. Multidrug Resistance.- References.