Theoretical Molecular Biophysics

2010
ISBN: 978-3-642-26411-5
Verlag: Springer

Buch, Englisch, 371 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 587 g

Reihe: Biological and Medical Physics, Biomedical Engineering

Biophysics deals with biological systems, such as proteins, which ful?ll a va- ety of functions in establishing living systems. While the biologistuses mostly a phenomenological description, the physicist tries to ?nd the general c- cepts to classify the materials and dynamics which underly speci?c processes. The phenomena span a wide range, from elementary processes, which can be induced by light excitation of a molecule, to communication of living s- tems. Thus, di?erent methods are appropriate to describe these phenomena. From the point of view of the physicist, this may be Continuum Mechanics to deal with membranes, Hydrodynamics to deal with transportthrough vessels, Bioinformatics to describe evolution, Electrostatics to deal with aspects of binding, Statistical Mechanics to account for temperature and to learn about the role of the entropy, and last but not least Quantum Mechanics to und- stand the electronic structure of the molecular systems involved. As can be seen from the title, Molecular Biophysics, this book will focus on systems for which su?cient information on the molecular level is available. Compared to crystallizedstandard materials studied in solid-state physics, the biological systems arecharacterizedby verybig unit cells containingproteinswith th- sands of atoms. In addition, there is always a certain amount of disorder, so that the systems can be classi?ed as complex. Surprisingly, the functions like a photocycle or the folding of a protein are highly reproducible, indicating a paradox situation in relation to the concept of maximum entropy production.

Zielgruppe

Graduate

Autoren/Hrsg.

Fischer, Sighart F.

Scherer, Philipp O.J.

Fachgebiete

• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik
• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

Statistical Mechanics of Biopolymers.- Random Walk Models for the Conformation.- Flory–Huggins Theory for Biopolymer Solutions.- Protein Electrostatics and Solvation.- Implicit Continuum Solvent Models.- Debye–Hückel Theory.- Protonation Equilibria.- Reaction Kinetics.- Formal Kinetics.- Kinetic Theory: Fokker–Planck Equation.- Kramers’ Theory.- Dispersive Kinetics.- Transport Processes.- Nonequilibrium Thermodynamics.- Simple Transport Processes.- Ion Transport Through a Membrane.- Reaction–Diffusion Systems.- Reaction Rate Theory.- Equilibrium Reactions.- Calculation of Reaction Rates.- Marcus Theory of Electron Transfer.- Elementry Photophysis.- Molecular States.- Optical Transitions.- The Displaced Harmonic Oscillator Model.- Spectral Diffusion.- Crossing of Two Electronic States.- Dynamics of an Excited State.- Elementry Photoinduced Processes.- Photophysics of Chlorophylls and Carotenoids.- Incoherent Energy Transfer.- Coherent Excitations in Photosynthetic Systems.- Ultrafast Electron Transfer Processes in the Photosynthetic Reaction Center.- Proton Transfer in Biomolecules.- Molecular Motor Models.- Continuous Ratchet Models.- Discrete Ratchet Models.- The Grand Canonical Ensemble.- Time Correlation Function of the Displaced Harmonic Oscillator Model.- The Saddle Point Method.