E-Book, Englisch, Band 256, 378 Seiten, eBook
Fiorucci / Distrutti Bile Acids and Their Receptors
1. Auflage 2019
ISBN: 978-3-030-22005-1
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: 1 - PDF Watermark
E-Book, Englisch, Band 256, 378 Seiten, eBook
Reihe: Handbook of Experimental Pharmacology
ISBN: 978-3-030-22005-1
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: 1 - PDF Watermark
Zielgruppe
Research
Autoren/Hrsg.
Weitere Infos & Material
Preface.- Part 1. Bile acids as signaling molecules and their receptors.- 1. A short history of bile acid pharmacology.- 2. Bile acids activated receptors: a review of GPBAR1 (TGR5) and other G-protein-coupled receptors.- 3. Bile acid activated receptors: a review of FXR and other Nuclear receptors.- 4. The intestinal enterokine fibroblast growth factor 15/19 in bile acid metabolism.- 5. Signaling from intestine to the host. How bile acids regulate intestinal and liver immunity.- Part 2. General pharmacology of bile acid activated receptors and their ligands.- 6. Modeling of bile acid activated receptors as a tool for pharmacological development.- 7. Chemistry and pharmacology of GPBAR1 and FXR selective agonists, dual agonists and antagonists.- 8. Non steroidal FXR ligands: current status and clinical applications.- 9. Intestinal selective FXR agonists and their potential in treating liver and metabolic diseases.- Part 3. Bile acids and their derivatives as drugs.- 10. UDCA, Nor-UDCA and T-UDCA: a review of their mechanisms of action and clinical applications.- 11. Chenodeoxycholic acid: an update on its therapeutic appplications and safety profile.- 12. Obeticholic acid: a review of its mechanisms of action and clinical applications.- Part 4 . Bile acid activated receptors as therapeutic targets.- 13. Targeting FXR in cholestasis.- 14. FXR agonists for the treatment of NASH and other metabolic disorders.- 15. Targeting bile acids activated receptors in bariatric surgery.