Neurodegeneration in Multiple Sclerosis

2007
ISBN: 978-88-470-0390-3
Verlag: Springer Milan

Buch, Englisch, 236 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 593 g

Reihe: Topics in Neuroscience

Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.

Zielgruppe

Research

Autoren/Hrsg.

Filippi, M.

Comi, G.

Rovaris, M.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Radiologie, Bildgebende Verfahren
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Nuklearmedizin, PET, Radiotherapie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Neuroradiologie

Inhaltsverzeichnis

Background.- Neuropathological Advances in Multiple Sclerosis.- Neurophysiology.- MRI Techniques to Assess Neurodegeneration.- Atrophy.- T1 Black Holes and Gray Matter Damage.- Magnetization Transfer Imaging.- Perfusion MR I.- Diffusion-Weighted Imaging.- Proton MR Spectroscopy.- Functional MRI.- Evaluation of MRI Outcomes.- Validation of MRI Surrogates.- Defining Responders and Non-responders.- Predictive Models in Multimodal Imaging.- Lessons from Other Neurodegenerative Diseases.- Alzheimer’s Disease.- Other Neurodegenerative Conditions.- Incorporation of Other Biomarkers.- Designing MS Trials for Neurodegeneration.- Critical Review of Existing Trials.- Design for the Next Trials of Neurodegeneration.

Über Autor(innen)

Dr. Massimo Filippi was born in 1961, took his Graduation in Medicine in 1986 and his Post-Degree Graduation in Neurology in 1990. His research activity has always been focussed on the use of MR-based technology to improve our understanding of how neurological diseases determine progressive accumulation of irreversible physical disability and cognitive impairment.

Dr. Filippi is member of various Scientific Societies and, in some of them, he covered or is covering institutional roles. He is also member of the Editorial Boards of many international scientific journals and acts as a reviewer on a regular basis for several others. He is author or co-author of more than 450 scientific papers published on peer-reviewed journals.

Dr. Filippi is currently Dierctor of the Neuroimaging Research Unit (NRU), Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, where he is also Non-Tenured Professor of Clinical Neurology. From 2005 he is also Director of the NMR Unit, Centro "S. Maria Nascente" IRCCS Fondazione Don Gnocchi, Milan.