Evans Animal Hematotoxicology

A Practical Guide for Toxicologists and Biomedical Researchers
1. Auflage 2008
ISBN: 978-1-4200-8010-0
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 224 Seiten

Hematology data from in vivo toxicology studies remains one of  the most predictive measures for human risk, as the same measurements made in pre-clinical toxicology studies can be made in early clinical trials. Covering the three main blood cell types – erythrocytes, leukocytes and thrombocytes, this work is designed to clarify topics for new entrants to the fields of laboratory animal hematology and toxicology, especially those topics where the rules for human hematology do not always apply. An entire chapter is devoted to immunotoxicology, a scientific discipline that is closely aligned with hematology. The text also addresses pre-analytical and analytical variables that affect animal studies, as these play a far more important part when interpreting data in contrast to humans where many of these variables can be well controlled or have less physiological effect. Information has been collated from published papers, textbooks and unpublished data: Readers are provided with key references to encourage further study

Zielgruppe

Toxicologists, hematologists, and lab animal and biomedical researchers; students in these areas.

Autoren/Hrsg.

Evans, G.O.

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Tierpathologie

Inhaltsverzeichnis

Introduction and Developing Areas of Interest
Hemopoiesis, Blood Cell Types, and Bone Marrow Examination
Erythrocytes, Anemias, and Polycythemias
Additional Erythrocytic Measurements
Iron, Associated Proteins, and Vitamins
Leukocytes
Immunotoxicology
Hemostasis
Appendices:

References for Laboratory Animal Hematology Data
SI Units and Conversions
Expectable Ranges
General Abbreviations
Some Common Biochemical Abbreviations
Compounds Causing Reductions and Destruction of Erythrocytes
Compounds Causing Reductions of Neutrophil Numbers
Compounds Affecting Numbers, Function, and Aggregation of Platelets
Leukocyte—Cluster of Differentiation

Über Autor(innen)

Following several senior positions and 13 years in health service laboratories, G. O. Evans left the post of principal clinical chemist at Birmingham Children’s Hospital, England, to enter the field of laboratory animal toxicology and clinical pathology. He was head of clinical pathology at Wellcome Research Laboratories, Beckenham, England, moving to join Astra Charnwood, and later the two AstraZeneca sites in the United Kingdom as director of clinical pathology.
Evans is now a director of A. George Owen and Company. He was the editor of and a contributor to a number of chapters of the book Animal Clinical Chemistry: A Primer for Toxicologists. In addition to lecturing at various universities in the UK, he has published over 40 papers on animal clinical pathology and toxicology. Other activities have included membership on the editorial board of the journal Laboratory Animals for over 15 years, and he has served as scientific secretary, chairman, and now is a lifetime honorary member of the Association of Comparative Clinical Pathology, UK.