The Blood Brain Barrier and Inflammation

1. Auflage 2017
ISBN: 978-3-319-45512-9
Verlag: Springer International Publishing

Buch, Englisch, 286 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 5608 g

Reihe: Progress in Inflammation Research

This PIR volume presents a comprehensive collection of reviews that focus on the role of the blood-brain barrier (BBB) during steady-state and inflamed conditions. Within the central nervous system (CNS) the constantly changing bloodstream is strictly separated from the CNS parenchyma by the BBB. However, viruses, bacteria, parasites and auto-aggressive immune cells can penetrate the barrier and significantly contribute to CNS inflammation. The BBB can actively contribute to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alterations of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential to the development of new drugs to efficiently combat inflammatory diseases of the CNS.

Zielgruppe

Research

Autoren/Hrsg.

Enzmann, Gaby

Lyck, Ruth

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Infektionskrankheiten
• Naturwissenschaften Biowissenschaften Proteinforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft

Inhaltsverzeichnis

General Introduction to Barrier Mechanisms in the Central Nervous System.- Topological Aspects of the Blood-brain and Blood cerebrospinal Fluid Barriers and their Relevance in Inflammation Research.- The Contribution of the Extracellular Matrix to the BBB in Steady State and Inflammatory Conditions.- Pathophysiology of the Bloodbrain Barrier in Neuroinflammatory Diseases.- Leakage at Blood-neural Barriers.- Blood-Brain Barrier Transporters and Neuroinflammation: Partners in Neuroprotection and in Pathology.- MicroRNAs in Brain Endothelium and Inflammation.- Blood-Brain Barrier Dysfunction during Central Nervous System Autoimmune Diseases.- Pathways Across the Blood Brain Barrier.- Neuroinflammation in Bacterial Meningitis.- Blood Vessels in the Brain: a Signaling Hub in Brain Tumor Inflammation.

Über Autor(innen)

Ruth Lyck (PD, PhD), group leader, Theodor-Kocher-Institute, Bern, Switzerland, works on extravasation of immune cells or metastasing cancer cells across the blood brain barrier. Gaby Enzmann (PhD), Research Associate, Theodor-Kocher-Institute, Bern, Switzerland, works on immune cell trafficking across the brain barriers into the central nervous system.