Zebrafish Models of Neurodegenerative Disorders

1. Auflage 2025
ISBN: 978-1-032-66046-2
Verlag: Taylor & Francis Ltd

Buch, Englisch, 220 Seiten, Format (B × H): 210 mm x 280 mm, Gewicht: 453 g

Reihe: Neuroscience of Neurodegenerative Disease

Zebrafish are becoming a fascinating new animal model for a variety of neurodegenerative diseases such as Parkinson’s disease, Alzheimer‘s disease, multiple sclerosis and other demyelinating diseases. Zebrafish produce a lot of embryos, grow quickly, are optically clear, and are receptive to genetic modification. They are therefore superior to current in vivo models in that they may be used to study neurological illnesses and create high-throughput drug screens. This book presents information on the use of zebrafish as a model organism in the modeling of neurodegenerative diseases with contributions from experts in the field. The general characteristics of zebrafish as a model organism are reviewed and neurogenesis and its regulation in zebrafish embryos is explained. Information about the use of zebrafish in NGS diseases such as Parkinson's, Alzheimer's and multiple sclerosis is presented. It is aimed to explain both toxin-induced and genetic models of separately.

Zielgruppe

Academic and Professional Reference

Autoren/Hrsg.

Emekli-Alturfan, Ebru

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Medizinische Diagnose und Diagnostik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Geriatrie, Gerontologie
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)

Über Autor(innen)

Dr. Ebru Emekli-Alturfan received her PhD in biochemistry from the University of Marmara in 2006 and was appointed as a professor in the Faculty of Dentistry at Marmara University, specifically within the Department of Basic Medical Sciences in 2016. Ebru Emekli-Alturfan leads a research group using Zebrafish as a model organism to investigate molecular mechanisms of neurodegeneration. Their research encompasses neurodegeneration, neurodevelopment, and its molecular regulation in vertebrate development. They use zebrafish as a main model system. To investigate the genetic foundation of human diseases, they work together with colleagues both within the Medical and Dental School and internationally to develop and implement in vivo models. Besides leading a research group, Ebru Emekli-Alturfan teaches medical biochemistry courses at Marmara University's Faculty of Dentistry and Institute of Health Sciences.