Ekins / Xu Drug Efficacy, Safety, and Biologics Discovery

Emerging Technologies and Tools
1. Auflage 2009
ISBN: 978-0-470-43180-1
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 400 Seiten, E-Book

Reihe: Wiley Series on Technologies for the Pharmaceutical

Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.

Autoren/Hrsg.

Ekins, Sean

Xu, Jinghai J.

Inhaltsverzeichnis

Preface.
Acknowledgments.
Contributors.
PART I: DRUG EFFICACY AND SAFETY TECHNOLOGY.
1. Focus on Fundamentals: Towards Better Therapeutic IndexPrediction (Jinghai J. Xu and Li J. Yu).
2. High-Throughput Protein-Based Technologies and ComputationalModels for Drug Development, Efficacy and Toxicity (Leonidas G.Alexopoulos, Julio Saez-Rodriguez and Christopher W. Espelin).
3. Cellular Systems Biology Applied to Pre-Clinical SafetyTesting: A Case Study of CellCiphr¯TMProfiling (Lawrence Vernetti, William Irwin, Kenneth A. Giuliano,Albert Gough, Kate Johnston and D. Lansing Taylor).
4. Systems Pharmacology, Biomarkers and Biomolecular Networks(Aram Adourian, Thomas N. Plasterer, Raji Balasubramanian, EzraJennings, Shunguang Wang, Jan van der Greef, Robert McBurney,Pieter Muntendam, and Noubar Afeyan).
5. Zebrafish Models for Human Diseases and Drug Discovery(Hanbing Zhong, Ning-Ai Liu and Shuo Lin).
6. Toxicity Pathways and Models: Mining for Potential SideEffects (Sean Ekins and Josef Scheiber).
7. Computational Systems Biology Modeling of Dosimetry andCellular Response Pathways (Qiang Zhang, Yu-Mei Tan, SudinBhattacharya and Melvin E. Andersen).
8. Stem Cell Technology for Embryotoxicity, Cardiotoxicity andHepatotoxicity Evaluation (Julio C. Davila, Donald B. Stedman,Sandra J. Engle, Howard I. Pryor II and Joseph P. Vacanti).
9. Telemetry Technology for Preclinical Drug Discovery andDevelopment (Yi Yang).
PART II. BIOLOGICS TECHNOLOGY.
10. Nanotechnology to Improve Oral Drug Delivery (Mayank D.Bhavsar, Shardool Jain, and Mansoor M. Amiji).
11. Functional Glycomics and the Future of Glycomic Drugs (RamSasisekharan).
12. Modeling Efficacy and Safety of Engineered Biologics (JeffChabot and Bruce Gomes).
13. Regulation of Gene Expression by Small, Non-Coding RNAs:Practical Applications (Roman Herrara and Eric Tien).
PART III. FUTURE PERSPECTIVE.
14. Future Perspectives of Biological Engineering inPharmaceutical Research: The Paradigm of Modeling, Mining,Manipulation and Measurements (Jinghai J. Xu, Sean Ekins, MichaelMcGlashen and Douglas Lauffenburger).
Index.

Über Autor(innen)

Sean Ekins, MSc, PHD, DSc, is the Principal at Collaborations inChemistry; and Adjunct Associate Professor in the Department ofPharmaceutical Sciences at the University of Maryland, School ofPharmacy. Dr. Ekins has published widely on ADME/Tox, systemsbiology, computational, and in vitro drug discovery approaches. Hehas previously edited two Wiley books: Computer Applications inPharmaceutical Research and Development (2006) and ComputationalToxicology: Risk Assessment for Pharmaceutical and EnvironmentalChemicals (2007).
Jinghai J. Xu, PHD, is Director of Automated Biotechnology atMerck. Previously he headed predictive toxicology at Pfizer, wherehe led research activities in drug-induced liver injury, genetictoxicology, drug transporters, assay development, high contentscreening, in vitro in vivo correlations, systems biology, andsystems toxicology. Dr. Xu has served on steering committees ofacademic-industry and industry-industry collaborations, and as aguest lecturer at the Massachusetts Institute of Technology.