Economic Evaluation in Genomic and Precision Medicine

Erscheinungsjahr 2023
ISBN: 978-0-12-813382-8
Verlag: Elsevier Science Publishing Co Inc

Buch, Englisch, 264 Seiten, Format (B × H): 234 mm x 191 mm, Gewicht: 364 g

Economic Evaluation in Genomic and Precision Medicine provides an in-depth examination of essential concepts, protocols and applications of economic evaluation in genomic and precision medicine. Contributions from leading international medical geneticists and health economists compile new ways to effectively assess the costs and outcomes of different genomic care pathways, implement cost-effective medical interventions, and enhance the value of genomic and precision healthcare. Foundational chapters and discipline-specific case studies cover topics ranging from the economic analysis of genomic trial design, to health technology assessment of next-generation sequencing, ethical aspects, economic policy in genomic medicine, and pricing and reimbursement in clinical genomics.

Zielgruppe

<p>bioscientists; human geneticists; biotech industry professionals; undergraduate and graduate students in health economics and health sciences, namely medicine, pharmacy, genetics; clinicians and health managers; public health officers, health policy makers; governmental organizations; health care professionals; hospital managers</p>

Autoren/Hrsg.

Weitere Mitwirkende

Mitropoulou, Christina

Wordsworth, Sarah

Buchanan, James

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften DNA und Transgene Organismen

Inhaltsverzeichnis

1. Introduction to economic evaluation in health sciences
2. Foundations of pharmacogenomics and personalized medicine

3. Economic evaluation of genome-guided treatment in oncology
4. Economic evaluation of rare diseases and the diagnostic odyssey
5. Economic analysis of pharmacogenetic testing for HLA-based adverse drug reactions
6. Economic evaluation of personalized medicine interventions in medium- and low-income countries with poor proliferation of genomics and genetic testing
7. Theoretical models for economic evaluation in genomic and personalized medicine
8. Using big data in economic evaluations in genomics: Challenges and opportunities
9. Assessing the stakeholder environment and views towards implementation of personalized medicine in a healthcare setting
10. Feasibility for pricing, budget allocation, and reimbursement of personalized medicine interventions

Über Autor(innen)

Buchanan, James
James Buchanan PhD joined the Health Economics Research Centre in 2005 and works predominantly on projects examining the economics of translating genomic high-throughput technologies from research into clinical practice, especially in cancer and infectious disease. In 2011 he was awarded a National Institute for Health Research Doctoral Research Fellowship to undertake a PhD in Health Economics investigating issues related to the economic analysis of genomic diagnostic technologies for multifactorial genetic diseases in the UK NHS, based on a study evaluating a targeted array in haematological cancers. Previous genomics projects include an economic evaluation of the use of genetic testing to identify the somatic mutations that can cause common cancers, an economic evaluation of the use of genetic tests to identify gastrointestinal pathogens to improve hospital infection control practice, the development of an economic modelling framework to evaluate novel genomic diagnostic tools in inflammatory bowel disease, and a cost-effectiveness analysis of microarray technology in the UK National Health Service. His other interests include costing methodology and the valuation of patient preferences. He also teaches on a range of undergraduate and postgraduate courses at the University of Oxford, and teaches advanced cost-effectiveness analysis methods to health economists and policy makers.

Mitropoulou, Christina
Christina Mitropoulou is Managing Director and Principal Investigator at the Golden Helix Foundation (London, UK), a registered UK-Charity with Research and Educational activities in the field of Genomic and Personalized Medicine. Her research interests revolve around the health economic evaluation of genome-guided therapeutic interventions. Also, Christina Mitropoulou participates as Executive Committee member of the Ubiquitous Pharmacogenomics (U-PGx) project and coordinates the health economic evaluation of the PREPARE clinical study on pre-emptive Pharmacogenomics testing, involving approx. 8000 patients from 7 clinical sites and she is an active member of the Pharmacogenomics Access and Reimbursement Coalition.
Christina Mitropoulou has published several original articles on this topic in leading scientific journals and has edited two textbooks on economic evaluation in Genomic Medicine that are published by Elsevier/Academic Press.

Wordsworth, Sarah
Sarah Wordsworth is at the University of Oxford, Medical Sciences Division, Nuffield Department of Population Health, Oxford, UK.