Probability Models for DNA Sequence Evolution

2. 2008 Auflage 2008
ISBN: 978-0-387-78168-6
Verlag: Springer

Buch, Englisch, 431 Seiten, Format (B × H): 164 mm x 243 mm, Gewicht: 741 g

Reihe: Probability and Its Applications

Our basic question is: Given a collection of DNA sequences, what underlying forces are responsible for the observed patterns of variability? To approach this question we introduce and analyze a number of probability models: the Wright-Fisher model, the coalescent, the infinite alleles model, and the infinite sites model. We study the complications that come from nonconstant population size, recombination, population subdivision, and three forms of natural selection: directional selection, balancing selection, and background selection. These theoretical results set the stage for the investigation of various statistical tests to detect departures from "neutral evolution". The final chapter studies the evolution of whole genomes by chromosomal inversions, reciprocal translocations, and genome duplication.

Throughout the book, the theory is developed in close connection with data from more than 60 experimental studies from the biology literature that illustrate the use of these results. This book is written for mathematicians and for biologists alike. We assume no previous knowledge of concepts from biology and only a basic knowledge of probability: a one semester undergraduate course and some familiarity with Markov chains and Poisson processes.

Zielgruppe

Research

Autoren/Hrsg.

Durrett, Richard

Fachgebiete

• Interdisziplinäres Wissenschaften Wissenschaften: Forschung und Information Datenanalyse, Datenverarbeitung
• Naturwissenschaften Biowissenschaften Biowissenschaften DNA und Transgene Organismen
• Mathematik | Informatik Mathematik Stochastik Wahrscheinlichkeitsrechnung
• Mathematik | Informatik Mathematik Stochastik Mathematische Statistik
• Naturwissenschaften Biowissenschaften Biowissenschaften Evolutionsbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizinische Mathematik & Informatik

Inhaltsverzeichnis

Basic Models.- Estimation and Hypothesis Testing.- Recombination.- Population Complications.- Stepping Stone Model.- Natural Selection.- Diffusion Processes.- Multidimensional Diffusions.- Genome Rearrangement.

Über Autor(innen)

Rick Durrett received his Ph.D. in operations research from Stanford University in 1976. He taught in the UCLA mathematics department before coming to Cornell in 1985. He is the author of six books and 125 research papers, and is the academic father of more than 30 Ph.D. students. His current interests are the use of probability models in genetics and ecology, and decreasing the mean and variance of his golf.