Donnelly / Horton Vascular Complications of Diabetes

Current Issues in Pathogenesis and Treatment
2. Auflage 2008
ISBN: 978-0-470-75149-7
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 240 Seiten, E-Book

Diabetes has reached epidemic proportions, and the cardiovascularcomplications of diabetes are life-threatening and disabling. Thisbook is unique in providing a simple explanation of the biochemicalrole of PKC in diabetes complications, which allows clinicians tounderstand why PKC inhibitors (in development) are an excitingprospect for future treatment to slow progression of eye & footcomplications.
New features of this Second Edition include:
* * Updated throughout to reflect the impact of recent majorclinical trials on current clinical practice
* Includes a major new section on diabetic neuropathy
* Revised section on diabetic retinopathy
Each chapter is short and succinct, focusing on 'bestpractice'. There are key learning points at the end of eachchapter, with numerous helpful tables, figures and clinicalimages.

Autoren/Hrsg.

Donnelly, Richard

Horton, Edward

Inhaltsverzeichnis

CONTENTS.
List of contributors.
Preface.
SECTION 1. MICRO- AND MACROVASCULAR COMPLICATIONS OFDIABETES.
Chatper 1. The burden of diabetes complications.
Chapter 2. Risk factors.
Chapter 3. Diabetic nephropathy.
Chapter 4. Coronary heart disease and diabetes.
Chapter 5. Diabetes and cerebrovascular disease.
Chapter 6. Erectile dysfunction.
Chapter 7. Evidence0based interventions to prevent or retardvascular complications.
SECTION 2. DIABETIC RETINOPATHY AND ASSOCIATED OPHTHALMICDISORDERS.
Chapter 8. Diabetic retinpathy: epidemiology and riskfactors.
Chapter 9. Classification and diagnosis of diabeticretinopathy.
Chapter 10. Pathogenesis of diabetic retinopathy.
Chapter 11. Diabetic maculopathy.
Chapter 12. Proliferative diabetic retinopathy.
Chapter 13. Non-retinal diabetic ocular complications.
Chapter 14. Pictorial case studies.
SECTION 3. DIABETIC NEUROPATHY.
Chapter 15. Diabetic neuropathy: epidemiology and riskfactors.
Chapter 16. Classification and diagnosis of diabeticneuropathy.
Chapter 17. Pathogenesis of diabetic neuropathy.
Chapter 18. Treatment of diabetic neuropathy.
SECTION 4. PATHOGENESIS OF GLYCAEMIC VASCULARDYSFUNCTION.
Chapter 19. Pathophysiological mechanisms.
Chapter 20. Protein kinase C.
Chapter 21. Protein kinase C activation and vascularpermeability.
Chapter 22. Harmful effects of protein kinase C activation incardiovascular and renal tissues.
Chapter 23. Therapeutic potential for isoform-selective proteinkinase C inhibitors.
Index

Über Autor(innen)

Richard Donnelly MD PhD FRCP FRACP is Professor of Vascular Medicine at the University of Nottingham and Honorary Consultant Physician at the J. O'Neil Diabetic Centre, Derbyshire Royal Infirmary, Derby, UK