Devaux / Herrmann Transmembrane Dynamics of Lipids

1. Auflage 2011
ISBN: 978-1-118-12010-1
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 400 Seiten, E-Book

Reihe: Wiley Series in Protein and Peptide Science

The first and only book devoted entirely to MEMBRANE LIPIDASYMMETRY AND ITS BIOLOGICAL IMPLICATIONS
Transmembrane Dynamics of Lipids is comprised of contributionsfrom expert authors from leading research groups that presentup-to-date quantitative data on the formation, stability, andbiological consequences of the asymmetrical organization of lipidsin cell membranes.
Incorporating an impressive amount of new, previouslyuncollected data, the book examines transmembrane asymmetry andmovement of lipids in biological membranes, and methods for themeasurement of transmembrane lipid motion, emphasizing the role oflipid flippases and discusses biological functions associated withlipid asymmetry. In addition, it draws attention to important newdiscoveries in the field, such as the correlation betweenmalfunction of lipid flippases and human diseases such asthrombosis and cancer. The book also addresses the manifold methodsthat are used to measure the rate of transmembrane movement oflipids in biological and model systems.
The only guide to new discoveries regarding lipids in cellmembranes, Transmembrane Dynamics of Lipids is designed to appealto biophysicists, biochemists, and cellular and molecularbiologists working in the growing field of membrane research.

Autoren/Hrsg.

Herrmann, Andreas

Devaux, Phililp

Inhaltsverzeichnis

Introduction
List of Contributors.
Part I: ASSESSING TRANSMEMBRANE MOVEMENT AND ASYMMETRY OFLIPIDS.
1. Methods for the Determination of Lipid TransmembraneDistribution and Movement in Biological Membranes (Philippe F.Devaux and Andreas Herrmann).
2. Detection and Measurement of Unlabeled Lipid TransmembraneMovement(Iván López-Montero, Marisela Vélez andPhilippe F. Devaux).
Part II: LIPID ASYMMETRY IN CELL MEMBRANES.
3. New Insights in Membrane Lipid Asymmetry in Animal and PlantCells (Alain Zachowski).
4. Sphingolipid Asymmetry and Transmembrane Translocation inMammalian Cells (Gerrit van Meer, Sylvia Neumann, and PerHaberkant).
5. Transbilayer Movement and Distribution of Cholesterol(Peter Müller, Anna Pia Plazzo, and AndreasHerrmann).
Part III. ENERGY-INDEPENDENT PROTEIN-MEDIATED TRANSMEMBRANEMOVEMENT OF LIPIDS.
6. Phospholipid Flip-Flop in Biogenic Membranes (Anant K.Menon and Andreas Herrmann).
7. Phospholipid Scramblase: When Phospholipid Asymmetry GoesAway (Edouard M. Bevers and Patrick L. Williamson).
Part IV: ENERGY-DEPENDENT LIPID TRANSPORT ACROSSMEMBRANES.
8. Flip or Flop: Mechanism and (Patho)Physiology ofP4-ATPase-Catalyzed Lipid Transport (Patricia M.Verhulst, Joost C.M. Holthuis, and Thomas G. Pomorski).
9. Coupling Drs2p to Phospholipid Translocation, MembraneAsymmetry, and Vesicle Budding (Xiaoming Zhou, ParamasivamNatarajan, Baby-Periyanayaki Muthusamy, Todd R. Graham, and KeLiu).
10. Substrate Specifi city of the Aminophospholipid Flippase(Shelley M. Cook and David L. Daleke).
11. The Flippase Delusion? (Naomi L. Pollock, Petra H.M.Niesten, and Richard Callaghan).
Part V: RELEVANCE OF LIPID TRANSMEMBRANE DISTRIBUTIONFOR MEMBRANE PROPERTIES AND PROCESSES
12. Membrane Lipid Asymmetry and Permeability to Drugs: A Matterof Size (Adam Blanchard and Cyril Rauch).
13. Endocytosis and Lipid Asymmetry (Nina Ohlwein, AndreasHerrmann, and Philippe F. Devaux).
Part VI: APOPTOSIS AND DISEASES: CONSEQUENCES OF DISRUPTIONTO LIPID TRANSMEMBRANE ASYMMETRY
14. Membrane Lipid Asymmetry in Aging and Apoptosis(Krishnakumar Balasubramanian and Alan J. Schroit).
15. Phosphatidylserine Exposure in Hemoglobinopathies (FransA. Kuypers and Eric Soupene).
16. Scott Syndrome: More Than a Hereditary Defect of PlasmaMembrane Remodeling (Florence Toti and Jean-MarieFreyssinet).
17. ABCA1, Tangier Disease, and Lipid Flopping (Ana Zarubicaand Giovanna Chimini).

Über Autor(innen)

Philippe F. Devaux, PhD, is Professor of Physics at the Paris 7University.He has long-standing expertise in teaching molecular andcellular biophysics and physics applied to biology and medicine. Heis the author of almost two hundred scientific papers and threebooks, and is an Editor of the European Biophysics Journal.
Andreas Herrmann, PhD, is Professor of Molecular Biophysics atHumboldt-University of Berlin. He teaches courses on the subjectsof molecular; cell; and membrane biophysics, optical spectroscopy,and fluorescence microscopy. He is the author of more than twohundred scientific papers focusing on lipid dynamics in biologicalmembranes and molecular mechanisms of virus infection.