De Caterina / Libby Endothelial Dysfunctions and Vascular Disease

1. Auflage 2008
ISBN: 978-0-470-99409-2
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 432 Seiten, E-Book

Bridging the gap between the laboratory and the bedside, thistimely volume illuminates the connection between endothelialdysfunction and vascular disease. This comprehensive survey ofatherosclerotic disease begins with biology - incorporatingthe latest breakthroughs in the field - then elucidates riskfactors and diagnostic tools and markers. A major section onendothelium-directed prevention and therapy shows you how to applycutting-edge research to clinical care.
Under the careful editorial guidance of Drs. De Caterina andLibby, the highly-regarded contributors address:
- endothelial activation and the initiation ofatherosclerosis
- mechanisms of plaque progression and complications
- the role of LDL in the origin and progression ofatherosclerosis
- advanced glycation endproducts and the acceleratedatherosclerosis in diabetes
- oxidative stress and vascular disease
- soluble adhesion molecules as markers of vascular disease
- hormone-replacement therapy and cardiovascular risk
- anti-oxidants and endothelial protection
and more.
The first book dedicated to the central role of endothelialdysfunction in vascular disease, this concise volume gathers allthe latest information on the subject into one convenient andcohesive text. Make sure your patients are benefiting from currentknowledge by keeping a copy of Enothelial Dysfunctions in VascularDisease close at hand for frequent consultation.
Introduction
Every book has a history, this one not excepted, havingemerged from intersections in professional lives of the Editors.This book bears the fruits of a collaboration between the"pupil" (RDC) and the "mentor" (PL). Duringan extended sabbatical of the pupil in Boston in 1994, we probedtogether the concept that endothelial dysfunction served as acommon denominator of vascular disease, with the balance betweeninflammation and its inhibition as a fulcrum of the regulation ofthe behavior of endothelial cells. As practicing cardiologists inour clinical lives, we sought to link to endothelial function themechanisms of action of risk factors and of pharmacologic agentsused to treat and prevent vascular disease. The pupil thereforeauthored a few reviews on the mechanism of action of risk factorsand included them in a small book, published in Italian, for whichthe mentor wrote a preface. The book was greeted with favor fromthe Italian cardiological community, and provided the nidus for thepresent, more ambitious endeavor, which includes updated reviews onthe pathogenesis of vascular disease and on the most novel aspectsof vascular biology. This enterprise was enabled by thecontributions of many of our former or present collaborators andcolleagues, without whose enthusiasm and engagement this work couldnever have seen light. We largely underestimated the devotionnecessary on our own side at the beginning, but it ultimatelyyielded a product that we feel achieves our original goals. We areaware that we confront a continuously evolving topic, wherefrequent updates would be desirable - if not necessary. Yet, webelieve in the value of books - such as the current one - thatattempt to organize in a snapshot of time, the vast amount ofliterature available in a coherent and comprehensive scheme. We areaware of existing gaps, of emerging material not paid its due, andof the rapid evolution of some of the concepts highlighted within.The links between the laboratory and the clinic have never affordedmore opportunity for new understanding and advances in diagnosisand treatment than today We hope that our colleagues, vascularbiologists cardiologists, internists, and other physicians alikewill find this compendium a useful guide to this most exciting timein vascular biology and medicine
Raffaele De Caterina and Peter Libby

Autoren/Hrsg.

De Caterina, Raffaele

Libby, Peter

Inhaltsverzeichnis

Part I The basis of endothelial involvement in vasculardiseases.
1 Endothelial functions and dysfunctions.
Raffaele De Caterina, Marika Massaro, & PeterLibby.
2 Endothelial activation and the initiation ofatherosclerosis.
Raffaele De Caterina, Antonella Zampolli, GuidoLazzerini, & Peter Libby.
3 Mechanisms of plaque progression and complications.
Raffaele De Caterina, Antonella Zampolli, Serena DelTurco, & Peter Libby.
4 Angiogenesis in cardiovascular disease.
Karen S. Moulton.
Part II The endothelium and cardiovascular riskfactors.
5 VLDL and atherosclerosis.
Jan Nilsson, Mikko P.S. Ares, & Wolfgang Dichtl.
6 High-density lipoprotein and atheroprotection.
Brian Krause, Reynold Homan, & Roger Newton.
7 Advanced glycation endproducts and the acceleratedatherosclerosis in diabetes.
Giuseppina Basta, Ann Marie Schmidt, & Raffaele DeCaterina.
8 Homocysteine and endothelial dysfunction.
Rosalinda Madonna & Raffaele De Caterina.
9 Lipoprotein(a) and the artery wall.
Angelo M. Scanu & Marilena Formato.
10 Oxidative stress and vascular disease.
Dominik Behrendt & Peter Ganz.
11 Infections and vascular disease.
Amir Kol & Peter Libby.
Part III Diagnostic tools and markers of endothelialfunctions.
12 Endothelial vasodilatory dysfunction: basic concepts andpractical implementation.
Scott Kinlay & Peter Ganz.
13 Endothelial vasodilatory dysfunction and risk factors inadults.
Mark R. Adams & David S. Celermajer.
14 Endothelial vasodilatory dysfunction in early life.
Julian P.J. Halcox & John E. Deanfield.
15 Endothelial vasodilatory dysfunction in hypertension.
Umberto Campia & Julio A. Panza.
16 Vascular function and diabetes mellitus.
Mark A. Creager & Joshua A. Beckman.
17 Dyslipidemia and endothelial dysfunction: pathophysiology andtherapy.
Todd J. Anderson & Francois Charbonneau.
18 Soluble adhesion molecules as in vivo biohumoralmarkers of vascular cell activation.
Jacopo Gianetti & Raffaele De Caterina.
Part IV Endothelium-directed prevention and therapy.
19 Hormone replacement therapy and cardiovascular disease.
Tommaso Simoncini.
20 Anti-atherogenic effects of omega-3 fatty acids.
Antonella Zampolli, Erling Falk, & Raffaele DeCaterina.
21 Treatment of endothelial dysfunction and atherosclerosis bycholesterol lowering.
Masanori Aikawa & Peter Libby.
22 Antioxidants and endothelial protection.
Domenico Praticò.
23 Angiotensin-converting enzyme inhibitors and angiotensin IItype 1 receptor blockers to reverse endothelial dysfunction.
G.B. John Mancini & Sammy Y. Chan.
24 PPARs in atherosclerosis.
Ouliana Ziouzenkova, Nikolaus Marx, Peter Libby & JorgePlutzky.
25 Stem cells in atherosclerosis and atherosclerosis-relatedvascular disorders.
Yong-Jian Geng & Rosalinda Madonna.
26 Endothelium-targeted gene and cell-based therapy forcardiovascular disease.
Luis G.Melo, Alok S. Pachori, Deling Kong, MassimilianoGnecchi, & Victor J. Dzau.
Index

Über Autor(innen)

Raffaele De Caterina, MD. Director, Laboratory for Thrombosisand Vascular Research, CNR Institute of Clinical Physiology,Pisa
Dr. Peter Libby, MD. Chief, Cardiovascular Medicine, Brigham andWomen's Hospital. Mallinckrodt Professor of Medicine, HarvardMedical School