de Broe / Porter / Bennett Clinical Nephrotoxins

Renal Injury from Drugs and Chemicals
1998
ISBN: 978-94-015-9088-4
Verlag: Springer Netherland
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 481 Seiten, eBook

GEORGE A. PORTER information is an international commodity whose The field of clinical nephrotoxicity involves toxins of interpretation and application are strongly influenced diverse origin and exposure. A significant contribution by both the cultural and ethnic background of the to this problem arises from registered and non-regis observer. The opportunity to share in the rich diversity tered drugs either prescribed or purchased over the of the international scientific community was a fun counter. Another major contributor comes from occu pational or industrial exposures. Each situation pre damental goal of this endeavor. To participate as sents the nephrologist with unique challenges con equals leads to mutual respect and peer appreciation. cerning diagnosis, confirrnation, and treatment includ The sharing of intellectual resources which such an ing limitation from future exposure. In selecting drugs effort fosters, should facilitate the advancement of for inclusions in this book the editors were guided by sound science. both frequency and current knowledge. For occupa Our approach to the field of nephrotoxicity is from tionall environmental exposures similar guidelines the perspective of a book which will be of value to the were applied. As one reviews the world's literature clinician. In this respect we have chosen compounds concerning nephrotoxicity two types of investigation wh ich are of current importance to the nephrologist and his/her patient rather than of historical interest.

Zielgruppe

Research

Autoren/Hrsg.

de Broe, Marc E.

Porter, George A.

Bennett, William M.

Verpooten, G.A.

Inhaltsverzeichnis

A. General.- 1. Clinical relevance.- 2. Renal handling of drugs and xenobiotics.- 3. Immunologically-mediated toxin-induced renal diseases.- 4. Cellular mechanisms of nephrotoxity.- 5. Experimental models.- B. Specific Drugs.- Introduction: Anti-infectious agents.- 6. Aminoglycosides and vancomycin.- 7. The renal toxicity of beta-lactam antibiotics: Mechanisms and clinical implications.- 8. Amphotericin B.- 9. Miscellaneous drugs with nephrotoxic potential.- 10. Antiviral agents.- Introduction: Analgesic related renal injury.- 11. Analgesics.- 12. Nonsteroidal anti-inflammatory drugs: Effects on kidney function.- 13. 5-Aminosalicyclic acid and chronic interstitial nephritis.- 14. Nephrotoxicity of gold salts, D-penicillamine, and allopurinol.- 15. Renal injury from angiotensin I converting enzyme inhibitors.- 16. Diuretics.- 17. Anticancer: Cisplatin/carboplatin.- Introduction: Immunosuppressive drugs.- 18. Cyclosporine/tacrolimus (FK-506).- 19. OKT3 Nephrotoxicity: From acute tubular necrosis to hemolytic uremic syndrome.- 20. Cytokine associated renal dysfunction: Interleukins and interferons.- 21. Contrast associated nephropathy: Presentation, pathophysiology and management.- Introduction: Environmental nephrotoxins.- 22. Lead nephropathy.- 23. Cadmium-induced renal effects in the general environment.- 24. Mercury.- 25. Role of environmental/occupational exposure to organic solvents, silicon-containing compounds and pesticides in the development and progression of renal disease.- 26. Lithium and the kidney.- 27. Renal disease associated with illicit drug abuse.- 28. Renal toxicity of anesthetic agents.- 29. Nephrotoxicity of herbal remedies and trace elements used as food additives.- 30. Balkan nephropathy.- C. Prevention.- 31. Urinary biomarkers and nephrotoxicity.- 32. Principles of drug dosing in renal failure.- 33. Practical dosing.