Paraneoplastic Syndromes

Erscheinungsjahr 2011
ISBN: 978-0-19-977273-5
Verlag: Oxford University Press

Buch, Englisch, Band 79, 498 Seiten, Format (B × H): 259 mm x 188 mm

Reihe: Contemporary Neurology Series

Paraneoplastic syndromes, defined in this book as "disorders caused by cancer, but not a direct result of cancer invasion of the affected organ or tissue", once believed to be rare and esoteric neurologic disorders have assumed increasing importance as an explanation of neurologic and other symptoms in patients suffered from occult or controllable cancers. This book attempts a comprehensive review of paraneoplastic syndromes from considering both clinical and
pathophysiologic aspects. The book is divided into 4 sections: The first is an overview, classifying the disorders, describing a clinical approach to the diagnosis and treatment of paraneoplastic syndromes in general and identifying their pathogenesis. The second section discusses the clinical findings
and treatment of individual paraneoplastic syndromes with chapters dedicated to each of the neurologic syndromes and a chapter discussing nonneurologic syndromes such as endocrine, cutaneous, and rheumatologic paraneoplastic disorders. The third section discusses autoantibodies that characterize individual paraneoplastic syndromes. The final section discusses the paraneoplastic syndromes associated with individual cancers.

Autoren/Hrsg.

Darnell, Robert B.

Posner, Jerome B.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung

Inhaltsverzeichnis

Contents

SECTION 1 OVERVIEW

1. HISTORY
DEFINITIONS
CLASSIFICATION
HISTORY
Pathogenesis
EPIDEMIOLOGY
IMPORTANCE

2. CLINICAL FINDINGS, TREATMENT AND PROGNOSIS
INTRODUCTION
CLINICAL APPROACH
The Patient without Known Cancer The Patient with Known Cancer
CLUES TO DIAGNOSIS
Clinical Findings Laboratory Investigation
PATHOLOGY
TREATMENT
Plasma Exchange (Plasmapheresis) Intravenous Immunoglobulin
Rituximab Cyclophosphamide Corticosteroids Human Chorionic Gonadotropin Recommendations
PROGNOSIS

3. PATHOGENESIS
INTRODUCTION
HISTORICAL VIEWS
Toxic Substances Competition for Essential Substrate Bullet Opportunistic Infection Immune Mediated
CURRENT CONCEPTS OF PATHOGENESIS
Unresolved Questions Conclusions
ANIMAL MODELS

SECTION 2 CLINICAL SYNDROMES

4. BRAIN (CEREBRUM)
INTRODUCTION
CEREBRAL CORTEX
WHITE MATTER DEMYELINATION
BLOOD VESSELS (VASCULITIS)
HIPPOCAMPUS/LYMBIC ENCEPHALITIS
Clinical Findings Laboratory Findings Differential Diagnosis Pathology Pathogenesis Treatment
HYPOTHALAMUS
BASAL GANGLIA/THALAMUS
COGNITIVE/BEHAVIORAL ABNORMALITIES
Depression
ENCEPHALOMYELITIS

5. BRAIN (CEREBELLUM AND BRAINSTEM)
INTRODUCTION
BRAINSTEM
Opsoclonus/Myoclonus Brainstem Encephalitis
CEREBELLUM
Clinical Findings Laboratory Findings Pathology Pathophysiology Diagnosis Trea tment Prognosis

6. SPINAL CORD
INTRODUCTION
TRANSVERSE MYELOPATHY
Inflammatory Myelopathy/Myelitis Necrotizing Myelopathy Demyelinating Myelopathy Bullet Neuromyelitis Optica Inflammatory Myelitis
FOCAL MYELOPATHY
Focal Demyelinating Myelopathy Motor Neuron Disease (ALS) Stiff Person Syndrome
MOVEMENT DISORDERS
Myoclonus

7. CRANIAL NERVES
TASTE AND SMELL
VISUAL DISTURBANCES
Carcinoma Associated Retinopathy (CAR) Melanoma Associated Retinopathy (MAR) BDUMP Optic Neuropathy Uveitis/Vitreitis Oculomotor Neuropathy Proptosis
TRIGEMINAL NEUROPATHY
ACOUSTIC/VESTIBULAR NEUROPATHY
OTHER CRANIAL NERVES

8. DORSAL ROOT GANGLIA AND PERIPHERAL NERVES
INTRODUCTION
DORSAL ROOT GANGLION (PSN)
Clinical Features Pathology/Pathogenesis Bullet Diagnosis Treatment
PERIPHERAL NERVE SYNDROMES
Sensory Neuropathy Sensorimotor Neuropathy Guillain-Barré Syndrome Motor Neuropathy Autonomic Neuropathy Bullet Paraproteinemias Leukemia/Lymphoma Vasculitic Neuropathy Focal Neuropathies

9. NEUROMUSCULAR JUNCTION AND MUSCLE
INTRODUCTION
NEUROMUSCULAR JUNCTION
Lambert-Eaton Myasthenic Syndrome Myasthenia Gravis Peripheral Nerve Hyperexcitability
MUSCLE
Inflammatory Myopathies (Myositis)Necrotizing Myopathy Polymyalgia Rheumatica Bullet Myotonia

10. SYSTEMIC SYNDROMES (WITH NEUROLOGIC IMPLICATIONS)
INTRODUCTION
ENDOCRINE SYNDROMES
Cushing Syndrome Hypercalcemia SIADH Hypoglycaemia Hyperthyroidism
RHEUMATOLOGIC SYNDROMES
Arthropathy Fasciitis
AUTOIMMUNE SYNDROMES
Lupus Scleroderma Raynaud's Syndrome Digital Ischemia Still Disease
RHEUMATIC VASCULITIDES
OTHER RHEUMATIC DISORDERS
Complex Regional Pain Syndrome Erythromelalgia
PANNICULITIS
DERMATOLOGIC SYNDROMES
Skin Hair/Nail Disorders Cutaneous Vascular Disorders Oral
BONE DISORDERS
Osteomalacia
SYSTEMIC DISORDERS
Cachexia Fever Vasculopathy Other Organ Disorders

SECTION 3 ANTIBODIES

11. NUCLEAR/NUCLEOLAR ANTIBODIES
ANTI-HU
Antibody Antigen Gene Anti-Hu Syndrome
ANTI-RI
Antibody Antigen Gene Animal Models Clinical Findings Treatment/Prognosis
ANTI-MA (MA-1/MA-2)
Antibodies Antigen Gene Clinical Findings Treatment/Prognosis
ANNA-3
Anti-Zic
SOX (ANTI GLIAL NUCLEAR ANTIBODY)
Antibody Antigen

12. CYTOPLASMIC ANTIBODIES
INTRODUCTION
AN

Über Autor(innen)

Dr. Darnell studied neurology as Chief Resident with Dr. Fred Plum at The New York Hospital, Cornell, and then, beginning in 1990 and continuing through the present time, with Dr. Jerome Posner at Memorial Sloan-Kettering Cancer Center. Dr. Darnell is currently the Heilbrunn Cancer Professor and Senior Physician at The Rockefeller University and an Investigator with the Howard Hughes Medical Institute, and is an Affiliate Attending Neurologist at Memorial
Sloan-Kettering Cancer Center.

Dr. Posner did a Neurology residency at the University of Washington under Dr. Fred Plum. C. Cotzias of Neuro-Oncology at Memorial Sloan-Kettering cancer Center and was recently in only clinical research professor ship from the American Cancer Society.