Cristini / Koay / Wang An Introduction to Physical Oncology

How Mechanistic Mathematical Modeling Can Improve Cancer Therapy Outcomes
1. Auflage 2017
ISBN: 978-1-4665-5136-7
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 204 Seiten

Reihe: Chapman & Hall/CRC Mathematical and Computational Biology

This book presents a theoretical multiscale modeling framework for the integration of processes spanning from molecular signaling to individual and collective cellular behavior to complex spatiotemporal dynamics at the tissue and organ levels. It then gives a detailed discussion on how to incorporate experimental and patient data into the modeling framework. The book also illustrates multiscale modeling approaches through several applications, including breast cancer and mammary gland development, lymphoma and leukemia growth, the investigation of biobarriers to chemotherapeutic drugs, and nanoparticle-based delivering strategies.

Zielgruppe

Theoretical biologists, biophysicists, and biomedical engineers; systems and computational biologists; and cancer researchers.

Autoren/Hrsg.

Cristini, Vittorio

Koay, Eugene

Wang, Zhihui

Fachgebiete

• Naturwissenschaften Physik Physik Allgemein
• Mathematik | Informatik Mathematik Numerik und Wissenschaftliches Rechnen Angewandte Mathematik, Mathematische Modelle
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Medizinische Biotechnologie

Inhaltsverzeichnis

Introduction: The biology and physics of cancer. Methods: Current state of the art in scale-specific modeling approaches. Multiscale modeling framework. Specific multiscale implementations. Modeling Applications: Cell lineages and the development of the mammary gland. Breast cancer drug response and the role of stem cells. Hematopoietic malignancies and the spread of lymphoma and acute lymphoblastic leukemia. Metastastic colorectal cancer and the role of diffusion in drug resistance. Passive vs. active transport I: Molecular motor/cargo intracellular dynamics. Passive vs. active transport II: Nanoparticle strategies for overcoming diffusion limitations to drugs.