Pharmaceutical Aspects of Oligonucleotides

1. Auflage 1999
ISBN: 978-0-7484-0841-2
Verlag: CRC Press

Buch, Englisch, Format (B × H): 189 mm x 238 mm, Gewicht: 871 g

Oligonucleotides diffuse poorly through biological barriers, including cell membranes. They are also rapidly degraded in vivo by nucleuses. Aiming to improve the administration of compounds, the book studies the development of nucleotide chemistry.

Autoren/Hrsg.

Couvreur, Patrick

Malvy, Claude

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

1. Mechanisms of Action of Antisense Oligonucleotides D.M. Tidd and R.V. Giles 2. Chemistry of Oligonucleotides J.W. Engels and E. Uhlmann 3. The Oligonucleotide Prodrug Approach: The Pro-oligonucleotides F. Morvan, J.-J. Vasseur, E. Vivès, B. Rayner and J.-L. Imbach 4. Peptide Nucleic Acids P.E. Nielsen 5. Peptide-mediated Delivery of Oligonucleotides E. Vivès and B. Lebleu 6. Polymeric Nanoparticles and Microparticles as Carriers for Antisense Oligonucleotides E. Fattal and P.