Conn The Receptors

Volume IV
1. Auflage 2014
ISBN: 978-1-4832-7326-6
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 446 Seiten, Web PDF

The Receptors, Volume IV deals with receptors for intracellular hormones, estrogen, and sex steroids as well as for dopamine, cholecystokinin, and corticotropin. The role of surface recognition receptors in disease is also discussed, along with receptors for plant auxin action and auxin transport. Comprised of 11 chapters, this volume begins with a detailed account of the ?-adrenergic receptor-coupled adenylate cyclase and the reconstitution of the functional interactions of its various purified components. The discussion then turns to the mechanism of action of steroid and thyroid hormones and how abnormalities in their receptors lead to disease; nuclear location of estrogen receptors; and the biochemistry of the fungal sex steroid receptors as well as the use of Achlya as a model system for the study of the mechanism of action of steroid hormones in general. Subsequent chapters focus on dopamine receptors; cholecystokinin receptor; corticotropin receptors; and the search for receptors that mediate sweetness. The book concludes with an analysis of endocrine receptors on lymphocytes and the integration of endocrine and immune systems, with emphasis on large granular lymphocytes. This monograph will be a valuable resource for students and practitioners in fields ranging from cell biology and biochemistry to physiology, endocrinology, and pharmacology.

Autoren/Hrsg.

Conn, P. Michael

Inhaltsverzeichnis

1;Front Cover;1
2;The Receptors;4
3;Copyright Page;5
4;Table of Contents;6
5;Preface;10
6;Contents of Previous Volumes;12
7;Chapter 1. The ß-Adrenergic Receptor-Coupled Adenylate Cyclase: Reconstitution of the Functional Interactions of the Various Purified Components;16
7.1;I. Introduction;17
7.2;II. Purification and Characterization of the Various Components of the Adenylate Cyclase System;19
7.3;III. Reconstitution Studies;26
7.4;IV. Summary;45
7.5;References;49
8;Chapter 2. Intracellular Hormone Receptor Defects and Disease;52
8.1;I. Introduction;52
8.2;II. Mechanism of Action of Hormones Acting via Intracellular Receptors: Recent Advances;54
8.3;III. Receptor Alterations in Pathological States: Theoretical Considerations;56
8.4;IV. Primary Hormone Receptor Defects;58
8.5;V. Acquired Receptor Alterations and Disease;73
8.6;VI. Clinical Significance of Intracellular Hormone Receptor Defects;77
8.7;References;79
9;Chapter 3. Surface Recognition Receptors and Disease;90
9.1;I. Introduction: Receptors, Acceptors, and Other Cell-Surface Recognition Sites;91
9.2;II. Recognition Sites Involved in Human Disease;92
9.3;III. Levels of Possible Receptor Dysfunction;93
9.4;IV. Examples of Receptor-Associated Dysfunction;95
9.5;V. Therapeutic Consequences of Receptor Properties;99
9.6;VI. Receptors and Oncogenes;103
9.7;VII. Evaluation of Receptors in Vivo;104
9.8;VIII. Summary;106
9.9;References;106
10;Chapter 4. Nuclear Location of Estrogen Receptors;112
10.1;I. Introduction;113
10.2;II. Cell Enucleation and Immunocytochemistry;115
10.3;III. Related Evidence;124
10.4;IV. The Estrogen Receptor as a Nuclear Protein;147
10.5;V. Summary;155
10.6;References;155
11;Chapter 5. A Sex Steroid Receptor in the Water Mold Achlya ambisexualis;164
11.1;I. Introduction to Achlya and the Fungal Sex Steroids;164
11.2;II. Characterization of Receptor-Binding Properties in Vitro;169
11.3;III. Comparisons with Other Steroid Receptors;177
11.4;References;182
12;Chapter 6. Dopamine Receptors;186
12.1;I. Introduction;186
12.2;II. Characterization of Dopamine Receptor Subtypes;192
12.3;III. Characteristics of Radioligand Binding to Dopamine Receptors;197
12.4;IV. Implications for Neurology and Psychiatry;214
12.5;References;219
13;Chapter 7. The Cholecystokinin Receptor;228
13.1;I. Introduction;228
13.2;II. Receptor-Binding Studies—Radioligand-Bindin g Assays;230
13.3;III. Autoradiographic Localization of CCK Receptors;236
13.4;IV. Biochemical Properties of the CCK Receptor;239
13.5;V. CCK Receptor Function;251
13.6;VI. Summary and Perspectives;255
13.7;References;256
14;Chapter 8. Detection and Characterization of Corticotropin Receptors;268
14.1;I. Introduction;268
14.2;II. Problems in Detecting ACTH Receptors;269
14.3;III. Detection and Characterization of Adrenal ACTH Receptors;273
14.4;IV. Photoaffinity Labeling of ACTH Receptors;279
14.5;V. Role of Calcium in the Actions of ACTH;284
14.6;References;286
15;Chapter 9. Receptors for Plant Auxin Action and Auxin Transport;290
15.1;I. Introduction;290
15.2;II. Binding Sites for Auxin Transport Inhibitors;292
15.3;III. Auxin Receptors;299
15.4;IV. Concluding Remarks;323
15.5;References;325
16;Chapter 10. The Search for Receptors That Mediate Sweetness;330
16.1;I. Introduction;331
16.2;II. Chemical Structure of Sweeteners;332
16.3;III. Biochemical Approaches to Understanding Sweet Receptors;347
16.4;IV. Electrophysiological and Behavioral Approaches in Animals;349
16.5;V. Psychophysical Studies in Humans;351
16.6;VI. Computer-Assisted Molecular Design;374
16.7;VII. Conclusion;382
16.8;References;382
17;Chapter 11. Endocrine Receptors on Lymphocytes: Integration of Endocrine and Immune Systems;394
17.1;I. Introduction;395
17.2;II. Hormones and Neurotransmitters;396
17.3;III. Autacoids;416
17.4;IV. Integration of Endocrine and Immune Systems with Emphasis on the Large Granular Lymphocytes;422
17.5;References;425
18;Index;440