Conn The Receptors

Volume III
1. Auflage 2014
ISBN: 978-1-4832-7313-6
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 442 Seiten, Web PDF

The Receptors, Volume III deals with receptors for interferons, hormones, and growth factors as well as for ?-aminobutyric acid, tuftsin, somatomedin, and insulin. Prolactin and nicotine receptors are also considered, along with the protein tyrosine kinase activity of hormone and growth factor receptors. Comprised of 12 chapters, this volume begins with a detailed account of secretory component (SC) as a receptor for polymeric immunoglobulins and the importance of SC-polymeric immunoglobulin A interactions in the mucosal immune system. The discussion then turns to interferon receptors and what is known about the fate of interferons and their receptors after binding; the use of muscimol in ligand-binding studies aimed at characterizing ?-aminobutyric acid receptors; and the role of protease nexins in the interaction of proteases with cells and in the regulation of proteolytic activity in the interstitial fluid immediately surrounding cells. Subsequent chapters focus on receptor regulation of phosphoinositides and calcium; effects of phospholipid turnover on receptor function; dynamics of tuftsin receptors; and the structure, function, and regulation of somatomedin receptors. The book also examines the internalization and intracellular processing of insulin receptors before concluding with an analysis of prolactin and nicotine receptors. This monograph will be a valuable resource for students and practitioners in fields ranging from cell biology and biochemistry to physiology, endocrinology, and pharmacology.

Autoren/Hrsg.

Conn, P. Michael

Inhaltsverzeichnis

1;Front Cover;1
2;The Receptors;4
3;Copyright Page;5
4;Table of Contents;6
5;Contributors;12
6;Dedication;14
7;Preface;16
8;Contents of Previous Volumes;18
9;Chapter 1. Secretory Component: The Receptor That Mediates External Secretion of Polymeric Immunoglobulins;22
9.1;I. INTRODUCTION;23
9.2;II. SYNTHESIS OF IgA-J-CHAIN POLYMERS AND THEIR MIGRATION TO SECRETORY COMPONENT-CONTAINING SECRETORY CELLS (EPITHELIAL CELLS AND HEPATOCYTES);29
9.3;III. MOLECULAR STRUCTURE AND BIOSYNTHESIS OF SECRETORY COMPONENT;34
9.4;IV. TISSUE DISTRIBUTION OF SECRETORY COMPONENT;45
9.5;V. SECRETORY COMPONENT-DEPENDENT BINDING, TRANSPORT, AND EXOCYTOSIS OF POLYMERIC IMMUNOGLOBULIN;49
9.6;VI. SUMMARY;61
9.7;REFERENCES;63
10;Chapter 2. Interferon Receptors;74
10.1;I. INTRODUCTION;74
10.2;II. DIRECT ANALYSIS OF THE INTERACTION OF INTERFERONS WITH MEMBRANE RECEPTORS;78
10.3;III. NATURE AND STRUCTURE OF INTERFERON RECEPTORS;85
10.4;IV. FATE OF CELL-BOUND INTERFERONS;94
10.5;V. CONCLUSIONS;103
10.6;REFERENCES;105
11;Chapter 3. Protein Tyrosine Kinase Activity of Hormone and Growth Factor Receptors;114
11.1;I. INTRODUCTION;115
11.2;II. EPIDERMAL GROWTH FACTOR RECEPTOR;117
11.3;III. PLATELET-DERIVED GROWTH FACTOR RECEPTOR;122
11.4;IV. INSULIN RECEPTOR;126
11.5;V. INSULINLIKE GROWTH FACTOR I RECEPTOR;131
11.6;VI. INHIBITORS OF PROTEIN TYROSINE KINASES;133
11.7;VII. SUBSTRATE SPECIFICITY OF THE GROWTH FACTOR-STIMULATED PROTEIN TYROSINE KINASES;134
11.8;VIII. PHYSIOLOGICAL ROLE OF TYROSINE PHOSPHORYLATION: FACT AND SPECULATION;140
11.9;IX. INTERACTION OF THE GROWTH FACTOR-STIMULATED KINASES WITH OTHER HORMONE-REGULATED KINASES;143
11.10;X. CONCLUDING REMARKS;145
11.11;REFERENCES;146
12;Chapter 4. Muscimol and Central Nervous System y-Aminobutyric Acid Receptors: Studies with Ligand-Binding Techniques;156
12.1;I. INTRODUCTION;157
12.2;II. EFFECTS OF MUSCIMOL ON GABA BINDING TO CNS SUBCELLULAR PARTICLES;157
12.3;III. CONSTANTS FOR [3H]MUSCIMOL BINDING TO CNS SUBCELLULAR PARTICLES;158
12.4;IV. SUBSTRATE SPECIFICITY OF [3H]MUSCIMOL BINDING;160
12.5;V. CNS REGIONAL AND SUBCELLULAR DIFFERENCES IN MUSCIMOL BINDING;160
12.6;VI. SOME FACTORS THAT AFFECT [3H]MUSCIMOL BINDING;164
12.7;VII. [3H]MUSCIMOL BINDING TO SOLUBILIZED RECEPTORS;165
12.8;VIII. [3H]MUSCIMOL BINDING TO BLOOD VESSELS OF THE CNS;165
12.9;IX. [3H]MUSCIMOL BINDING TO SUBCELLULAR PARTICLES PREPARED FROM TISSUE CULTURES;165
12.10;X. COMPARISON OF MUSCIMOL RECEPTORS AND GABA RECEPTORS;166
12.11;XI. RECENT STUDIES OF [3H]MUSCIMOL BINDING INRELATION TO PHYSIOLOGY, BEHAVIOR, AND NEUROLOGIC-PSYCHIATRIC DISORDERS OF MAN;166
12.12;XII. CONCLUDING COMMENTS;168
12.13;REFERENCES;169
13;Chapter 5. Protease Nexins: Secreted Protease Inhibitors That Regulate Protease Activity at or near the Cell Surface;174
13.1;I. INTRODUCTION;174
13.2;II. THE THROMBIN AND UROKINASE-BINDING PROTEASE NEXIN: PN OR PN-1;176
13.3;III. PN-2;184
13.4;IV. PN-3;187
13.5;V. SUMMARY;189
13.6;REFERENCES;190
14;Chapter 6. Receptor Regulation of Phosphoinositides and Calcium: A Mechanism for Thyrotropin-Releasing Hormone Action;194
14.1;I. INTRODUCTION;194
14.2;II. CALCIUM AND TRH ACTION;196
14.3;III. STIMULATION OF PHOSPHOLIPID METABOLISM;200
14.4;IV. INITIAL STUDIES OF THE EFFECTS OF TRH ON PHOSPHOLIPID METABOLISM;202
14.5;V. EFFECTS OF TRH ON POLYPHOSPHOINOSITIDE METABOLISM;209
14.6;VI. TRH-INDUCED PHOSPHOLIPASE C HYDROLYSIS OF PtdIns4,5Pz: CALCIUM DEPENDENT OR INDEPENDENT;217
14.7;VII. InsP3 AND DG AS INTRACELLULAR MEDIATORS;222
14.8;VIII. MODEL OF TRH ACTION;226
14.9;REFERENCES;228
15;Chapter 7. Phospholipid Turnover and Receptor Function;234
15.1;I. PHOSPHOLIPIDS AS RECEPTORS;234
15.2;II. PHOSPHOLIPID METHYLATION AND RECEPTOR ACTIVATION;237
15.3;III. DIRECT ACTIVATION OF PLASMA MEMBRANE PHOSPHOLIPASE A2 BY LIGANDS;238
15.4;IV. PHOSPHOINOSITIDES IN RECEPTOR ACTIVATION;240
15.5;V. INHIBITION BY VASOPRESSIN OF PLASMA MEMBRANE Ca2+ ,Mg2+-ATPase;249
15.6;VI. CELLULAR PROLIFERATION AND PHOSPHOINOSITIDE TURNOVER;250
15.7;VII. RELATIONSHIP BETWEEN Na+, Ca2+ AND PHOSPHOINOSITIDE BREAKDOWN;252
15.8;VIII. CONCLUSION;254
15.9;REFERENCES;255
16;Chapter 8. The Tuftsin Receptors;264
16.1;I. INTRODUCTION;264
16.2;II. SYNTHESIS OF RADIOLABELED TUFTSIN;266
16.3;III. BINDING OF [3H]TUFTSIN TO PHAGOCYTIC CELLS;268
16.4;IV. BINDING OF TUFTSIN TO LYMPHOCYTES;271
16.5;V. BINDING OF TUFTSIN TO VARIOUS CELLS;272
16.6;VI. DYNAMICS OF TUFTSIN RECEPTORS;272
16.7;VII. ARE MEMBRANE-ASSOCIATED EVENTS RELEVANT TO TUFTSIN'S ACTION?;275
16.8;VIII. RECEPTORS FOR TUFTSIN ON PLASMA MEMBRANES OF MACROPHAGES AND MACROPHAGELIKE CELLS;277
16.9;IX. ON THE RELATION BETWEEN TUFTSINS AND Fc RECEPTORS;284
16.10;X. TOWARD ISOLATION OF PURIFIED SOLUBLE TUFTSIN RECEPTOR;292
16.11;XI. TUFTSIN AND THE CHEMOTACTIC PEPTIDE RECEPTORS: SOME MUTUAL CONSIDERATIONS;293
16.12;REFERENCES;297
17;Chapter 9. Somatomedin Receptors: Structure, Function, and Regulation;302
17.1;I. SOMATOMEDIN: BACKGROUND;302
17.2;II. SOMATOMEDIN RECEPTORS: DISCOVERY AND DIVERSITY;308
17.3;III. STRUCTURAL ANALYSIS OF SOMETOMEDIN RECEPTORS;318
17.4;IV. IMMUNOLOGICAL STUDIES OF SOMATOMEDIN RECEPTORS;323
17.5;V. REGULATION OF SOMATOMEDIN RECEPTORS;328
17.6;VI. ROLE OF THE SOMATOMEDIN RECEPTOR IN SOMATOMEDIN AND INSULIN ACTION;334
17.7;REFERENCES;342
18;Chapter 10. The Internalization and Intracellular Processing of Insulin Receptors;352
18.1;I. INTRODUCTION;353
18.2;II. INTERNALIZATION OF INSULIN RECEPTORS;353
18.3;III. RECYCLING OF INSULIN RECEPTORS;362
18.4;IV. DEGRADATION OF INSULIN RECEPTORS;366
18.5;V. FUNCTIONAL SIGNIFICANCE OF THE INTERNALIZATION AND PROCESSING OF INSULIN RECEPTORS;370
18.6;VI. SUMMARY;371
18.7;REFERENCES;372
19;Chapter 11. The Prolactin Receptor;376
19.1;I. INTRODUCTION;376
19.2;II. GENERAL CHARACTERISTICS OF THE PROLACTIN RECEPTOR;377
19.3;III. BIOCHEMICAL CHARACTERIZATION OF THE PROLACTIN RECEPTOR;384
19.4;IV. PROLACTIN RECEPTOR ANTIBODIES;397
19.5;REFERENCES;407
20;Chapter 12. Nicotine Receptors in the Central Nervous System;414
20.1;I. INTRODUCTION;414
20.2;II. PHARMACOLOGICAL EVIDENCE FOR CENTRAL NICOTINE RECEPTORS;415
20.3;III. IN VITRO CHARACTERIZATION OF THE NICOTINE RECEPTOR;421
20.4;IV. CENTRAL LOCALIZATION OF RECEPTORS;427
20.5;V. FUNCTIONAL ROLE OF NICOTINE RECEPTORS;428
20.6;REFERENCES;430
21;Index;438