Conn Neurotoxins

1. Auflage 2013
ISBN: 978-1-4832-8488-0
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, Band Volume 8, 423 Seiten

Reihe: Methods in Neurosciences

The exquisite simplicity and potency of toxins have made them valuable probes of neural systems. This book presents a comprehensive compilation of techniques used for the preparation, handling, and, particularly, for the use of neurotoxins. Model systems are described in which these neurotoxins have been extremely valuable in developing an understanding of the cellular and molecular basis of secretion and electrophysiological events leading to altered cell function. - Convenient benchtop format - Methods presented for easy adaptation to new systems - A virtual 'A-B-C' of commonly used and available toxins - Comprehensive protocols included for the use of alpha toxin, apamin, batrachotoxin; botulina toxin, bungarotoxin; channel ligands: agonists and antagonists; capsaicin; charybdotoxin, ciguatoxin; Clostridium botulinum neurotoxin; cholera toxin (choleragen); conotoxin; dendrotoxin; endothelin; fasciculin; geographutoxin; latrotoxin; natural toxins; neosurgatoxin; palytoxin; pertussis toxin; resiniferatoxin; sarafotoxin; scorpion toxin; snake venom toxins

Autoren/Hrsg.

Conn, P. Michael

Leseproben

Contributors to Volume 8
Frances C.G. Alexander(12),     Protein Toxins Group, Division of Biologics, PHLS Centre for Applied Microbiology and Research, Salisbury, Wiltshire SP4 OJG, England A.J. Anderson(29),     Department of Physiology and Pharmacology, Strathclyde Institute for Drug Research, University of Strathclyde, Glasgow G1 1XW, Scotland M. Arita(22),     Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu 807, Japan Johanna Balvinsdottir(7),     Department of Biological Sciences, The Royal Danish School of Pharmacy, 2100 Ø Copenhagen, Denmark Evelyne Benoit(11),     Laboratoire de Physiologie Comparée, Unité Associée du Centre de la Recherche Scientifique, Université de Paris XI, 91405 Orsay, France Roland Benz(1),     Lehrstuhl für Biotechnologie, Universität Würzburg, D-8700 Würzburg, Germany Mordecai Blaustein(16),     Department of Physiology and Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201 Peter M. Blumberg(27),     Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Institutes of Health, National Cancer Institute, Bethesda, Maryland 20892 Jean-Philippe Breittmayer(17, 25),     Faculté de Médecine, Université de Nice, 06034 Nice, France Barry S. Brewster(2),     Jerry Lewis Muscle Research Center, Department of Pediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 ONN, England Carlos Cerveñansky(18),     Division of Neurochemistry, Instituto de Investigaciones Biológicas Clemente Estable, 11600 Montevideo, Uruguay Trinad Chakraborty(1),     Lehrstuhl für Mikrobiologie, Universität Würzburg, D-8700 Würzburg, Germany Jens Dencker Christensen(7),     Department of Biological Sciences, The Royal Danish School of Pharmacy, 2100 Ø Copenhagen, Denmark F. Clementi(6),     CNR Center of Cytopharmacology, Department of Medical Pharmacology, University of Milan, 20129 Milan, Italy Joan X. Comella(11),     Facultat de Medicina, Estudi General de Lleida, Universitat de Barcelona, Lleida E-25006, Spain Cyrus R. Creveling(3),     Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 Federico Dajas(18),     Division of Neurochemistry, Instituto de Investigaciones Biológicas demente Estable, 11600 Montevideo, Uruguay John W. Daly(3),     Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 Thu T. Dinh(9),     Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, Washington 99164 A. Esparis-Ogando(6),     CNR Center of Cytopharmacology, Department of Medical Pharmacology, University of Milan, 20129 Milan, Italy Bjarne Fjalland(7),     Department of Biological Sciences, The Royal Danish School of Pharmacy, 2100 Ø Copenhagen, Denmark Christian Frelin(17, 25),     Institut de Pharmacologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Sophia Antipolis, 06560 Valbonne, France Maria L. Garcia(10),     Department of Membrane Biochemistry and Biophysics, Merck Institute for Therapeutic Research, Rahway, New Jersey 07065 Margarita Garcia-Calvo(10),     Department of Membrane Biochemistry and Biophysics, Merck Institute for Therapeutic Research, Rahway, New Jersey 07065 C. Gotti(6),     CNR Center of Cytopharmacology, Department of Medical Pharmacology, University of Milan, 20129 Milan, Italy Claude Granier(28),     Laboratoire de Biochemie, Centre National de la Recherche Scientifique, Faculté de Médecine, 13326 Marseille Cedex 15, France John B. Harris(21),     Division of Neurobiology, School of Neurosciences, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne, NEZ 4AB, England A.L. Harvey(29),     Department of Physiology and Pharmacology, Strathclyde Institute for Drug Research, University of Strathclyde, Glasgow Gl 1XW, Scotland N.H. Himmelreich(20),     Department of Neurochemistry, A. V. Palladin Institute of Biochemistry, Ukrainian Academy of Sciences, 252030 Kiev, U.S.S.R. F. Izumi(22),     Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu 807, Japan Annette Jørgensen(7),     Department of Biological Sciences, The Royal Danish School of Pharmacy, 2100 Ø Copenhagen, Denmark Gregory J. Kaczorowski(10),     Department of Membrane Biochemistry and Biophysics, Merck Institute for Therapeutic Research, Rahway, New Jersey 07065 H. Kobayashi(22),     Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu 807, Japan Susan F. Law(26),     Department of Pharmacology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104 Anne-Marie Legrand(11),     Institut Territorial de Recherches Médicales Louis Malardé, Associé à l’Institute Pasteur, Papeete, Tahiti, Polynésie, Francaise Ida J. Llewellyn-Smith(13),     Center for Neuroscience and Department of Medicine, Flinders University School of Medicine, Bedford Park, South Australia 5042, Australia Karsten Lollike(7),     Institute of Medical Physiology and Biotechnology, Center for Signal Peptide Research, The Panum Institute, University of Copenhagen, 2200 N Copenhagen, Denmark Erwann P. Loret(28),     Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331 Jane B. Minson(13),     Center for Neuroscience and Department of Medicine, Flinders University School of Medicine, Bedford Park, South Australia 5042, Australia Françis Miranda(28),     Laboratoire de Biochemie, Centre National de la Recherche Scientifique, Faculté de Médecine, 13326 Marseille Cedex 15, France Jordi Molgo(4,...