Conn Gene Probes

1. Auflage 2014
ISBN: 978-1-4832-6785-2
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 478 Seiten

Methods in Neurosciences, Volume 1: Gene Probes is a compendium of papers that deals with the developments in molecular biology, cell biology, and electrophysiology. Section I deals with gene expression using the Xenopus Oocyte system for expression and cloning of neuroreceptors and channels. One paper presents a method in studying the molecules in the brain related to neurotransmitter receptors and to the voltage channels in the brain by ''transplanting'' functional neurotransmitter receptors into the membrane of frog oocytes. Section II describes in situ and solution hybridization and the continuation of in situ hybridization with immunohistochemistry. One paper discusses the benefits of using alkaline phosphatase-Dig-dUTP-labeled oligonucleotide probes in high-resolution in situ in terms of ease of performance, safety, and fast detection rendering. Section III addresses the screening, sequencing, and cloning, the process of which includes the rapid identification of DNA clones. One paper outlines the methods and materials that are used in such identification. Section IV explains lineage analysis and Section V discusses molecular pathology, including the molecular pathology of Alzheimer's disease. This collection can prove useful for geneticists, molecular scientists, and academicians involved in neuroscience and pharmacological sciences, as well as researchers in geriatrics.

Autoren/Hrsg.

Conn, P. Michael

Leseproben

Contributors to Volume 1

Mary Abood(15),     Department of Psychiatry, Nancy Pritzker Laboratory of Behavioral Neuroscience, Stanford University School of Medicine, Stanford, California 94305

C. Anthony Altar(15),     Pharmacological Sciences, Genentech, Inc., South San Francisco, California 94080

Frank Baldino, Jr.(16),     Cephalon, Inc., West Chester, Pennsylvania 19380

Michael V.L. Bennett(1),     Department of Neuroscience, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461

Mariann Blum(17),     Dr. Arthur M. Fishberg Research Center in Neurobiology, The Mount Sinai Medical Center, Mount Sinai School of Medicine, The Mount Sinai Hospital, New York, New York 10029

Jim Boulter(20),     Molecular Neurobiology Laboratory, The Salk Institute, San Diego, California 92138

Thomas O. Brock(18),     Biological Sciences Research Center, The University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina 27599

Connie Cepko(21),     Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115

John P. Coghlan(14),     Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria 3052, Australia

P. Michael Conn(13),     Department of Pharmacology, The University of Iowa, College of Medicine, Iowa City, Iowa 52242

Jack E. Dixon(19),     Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907

Daniel M. Dorsa(10)

Geriatric Research, Education, and Clinical Center, Veterans Administration Medical Center, Seattle, Washington 98108

Departments of Medicine and Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195

James H. Eberwine(15),     Department of Psychiatry, Nancy Pritzker Laboratory of Behavioral Neuroscience, Stanford University School of Medicine, Stanford, California 94305

Paul D. Gardner(20),     Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03756

Charles R. Gerfen(5),     Laboratory of Cell Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892

Marvin C. Gershengorn(3),     Division of Endocrinology and Metabolism, Department of Medicine, Cornell University Medical College and The New York Hospital, New York, New York 10021

A. Giaid(9),     Department of Histochemistry, Royal Postgraduate Medical School, University of London, Hammersmith Hospital, London W12 ONN, England

S.J. Gibson(9),     Department of Histochemistry, Royal Postgraduate Medical School, University of London, Hammersmith Hospital, London W12 ONN, England

Michel Goedert(23),     Medical Research Council (MRC), Laboratory of Molecular Biology, Cambridge CB2 2QH, England

Jim Haralambidis(14),     Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria 3052, Australia

J. Fielding Hejtmancik(13),     Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030

Gerald A. Higgins(11),     Department of Neurobiology and Anatomy, University of Rochester School of Medicine, Rochester, New York 14642

Kevin A. Kelley(22),     Dr. Arthur M. Fishberg Research Center in Neurobiology, The Mount Sinai Medical Center, Mount Sinai School of Medicine, The Mount Sinai Hospital, New York, New York 10029

John S. Kizer(18),     Departments of Medicine and Pharmacology, Biological Sciences Research Center, The University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina 27599

Leslie Kushner(1),     Department of Neuroscience, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461

Fernand Labrie(12),     MRC Group in Molecular Endocrinology, Laval University Medical Center, Sainte-Foy, Quebec, Canada G1V 4G2

John P. Leonard(4),     Department of Biological Sciences, The University of Illinois at Chicago, Chicago, Illinois 60607

Juan Lerma(1),     Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain

Michael E. Lewis(16),     Cephalon, Inc., West Chester, Pennsylvania 19380

Joseph T. McCabe(6),     Department of Anatomy, Uniformed Services University of the Health Sciences, Department of Defense, Bethesda, Maryland 20814

Vei H. Mah(11),     Department of Neurobiology and Anatomy, University of Rochester School of Medicine, Rochester, New York 14642

Ricardo Miledi(2),     Department of Psychobiology, Laboratory of Cellular and Molecular Neurobiology, University of California, Irvine, Irvine, California 92717

Margaret A. Miller(10),     Geriatric Research, Education, and Clinical Center, Veterans Administration Medical Center, Seattle, Washington 98108, and Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195

R. Nichols(19),     Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907

Yoram Oron(3),     Department of Psysiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69 978, Israel

Ian Parker(2),     Department of Psychobiology, Laboratory of Cellular and Molecular Neurobiology, University of California, Irvine, Irvine, California 92717

Georges Pelletier(12),     MRC Group in Molecular Endocrinology, Laval University Medical Center, Sainte-Foy, Quebec, Canada G1V 4G2

Jennifer D. Penschow(14),     Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria 3052, Australia

Donald W. Pfaff(6, 13),     Neurobiology and Behavior Laboratory, The Rockefeller University, New York, New York 10021

J.M. Polak(9),     Department of Histochemistry, Royal Postgraduate Medical School, University of London, Hammersmith Hospital, London W12 ONN, England

Scott Pownall(14),     Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria 3052, Australia

James L. Roberts(17),     Dr. Arthur M. Fishberg Research Center in Neurobiology, The Mount Sinai Medical Center, Mount Sinai School of Medicine, The Mount Sinai Hospital, New York, New York...