Lysophospholipid Receptors

Signaling and Biochemistry
1. Auflage 2013
ISBN: 978-0-470-56905-4
Verlag: Wiley

Buch, Englisch, 812 Seiten, Format (B × H): 163 mm x 236 mm, Gewicht: 1270 g

This state-of-the-art reference addresses lysophospholipids, a special kind of fat that has been found to have a growing number of receptors within the cell and that has important, natural roles in the body, being essential for normal reproduction, development, maturation and life. This book covers the biochemistry, interactions, and signaling of lysophospholipids as well as its potential for producing new therapies for a range of medically important human diseases. Bringing together current knowledge in lysophospholipid signaling, this represents a must-have book for all academic, industrial, and medical school and hospital libraries.

Autoren/Hrsg.

Chun, Jerold

Weitere Mitwirkende

Hla, Timothy

Spiegel, Sarah

Moolenaar, Wouter

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biochemie (med.)

Inhaltsverzeichnis

PREFACE ix

CONTRIBUTORS xi

1 LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR SIGNALING 1
Hope Mirendil, Mu-En Lin, and Jerold Chun

2 SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTORS 41
Bongnam Jung and Timothy Hla

3 GLOBAL GENE EXPRESSION PROGRAM OF LYSOPHOSPHATIDIC ACID (LPA)-STIMULATED FIBROBLASTS 61
Catelijne Stortelers and Wouter H. Moolenaar

4 IDENTIFICATION OF DIRECT INTRACELLULAR TARGETS OF SPHINGOSINE 1-PHOSPHATE (S1P) 71
Nitai C. Hait, Sheldon Milstien, and Sarah Spiegel

5 LYSOPHOSPHOLIPID RECEPTOR SIGNALING PLATFORMS: THE RECEPTOR TYROSINE KINASE–G PROTEIN-COUPLED RECEPTOR SIGNALING COMPLEX 85
Nigel J. Pyne and Susan Pyne

6 AUTOTAXIN: A UNIQUE ECTO-TYPE PYROPHOSPHODIESTERASE WITH DIVERSE FUNCTIONS 103
Hiroshi Yukiura and Junken Aoki

7 STUDIES ON AUTOTAXIN SIGNALING IN ENDOCYTIC VESICLE BIOGENESIS AND EMBRYONIC DEVELOPMENT USING WHOLE EMBRYO CULTURE AND ELECTROPORATION 121
Masayuki Masu, Seiichi Koike, Takuya Okada, and Kazuko Keino-Masu

8 STANDARDIZATION AND QUANTIFICATION OF LYSOPHOSPHATIDIC ACID COMPOUNDS BY NORMAL-PHASE AND REVERSED-PHASE CHROMATOGRAPHY–TANDEM MASS SPECTROMETRY 137
Jeff D. Moore, Shengrong Li, David S. Myers, Stephen B. Milne, H. Alex Brown, and Walter A. Shaw

9 SPHINGOSINE KINASES: BIOCHEMISTRY, REGULATION, AND ROLES 153
Melissa R. Pitman, Kate E. Jarman, Tamara M. Leclercq, Duyen H. Pham, and Stuart M. Pitson

10 FUNCTIONAL AND PHYSIOLOGICAL ROLES OF SPHINGOSINE 1-PHOSPHATE TRANSPORTERS 185
Atsuo Kawahara and Tsuyoshi Nishi

11 LIPID PHOSPHATE PHOSPHATASES AND SIGNALING BY LYSOPHOSPHOLIPID RECEPTORS 201
Ganesh Venkatraman and David N. Brindley

12 LIPID PHOSPHATE PHOSPHATASES: RECENT PROGRESS AND ASSAY METHODS 229
Andrew J. Morris, Susan S. Smyth, Abdel K. Salous, and Andrew D. Renault

13 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND CARDIOVASCULAR PATHOLOGY 265
Susan S. Smyth, Anping Dong, Jessica Whee

Über Autor(innen)

JEROLD CHUN, MD, PhD, is a Professor at The Scripps Research Institute in La Jolla, California, and is a pioneer in the field of lysophospholipid signaling.