Chromatin Signaling and Neurological Disorders

Volume 12
Erscheinungsjahr 2019
ISBN: 978-0-12-813796-3
Verlag: Elsevier Science

Buch, Englisch, 378 Seiten, Format (B × H): 193 mm x 236 mm, Gewicht: 930 g

Chromatin Signaling and Neurological Disorders, Volume Seven, explores our current understanding of how chromatin signaling regulates access to genetic information, and how their aberrant regulation can contribute to neurological disorders. Researchers, students and clinicians will not only gain a strong grounding on the relationship between chromatin signaling and neurological disorders, but they'll also discover approaches to better interpret and employ new diagnostic studies and epigenetic-based therapies. A diverse range of chapters from international experts speaks to the basis of chromatin and epigenetic signaling pathways and specific chromatin signaling factors that regulate a range of diseases.

In addition to the basic science of chromatin signaling factors, each disease-specific chapter speaks to the translational or clinical significance of recent findings, along with important implications for the development of epigenetics-based therapeutics. Common themes of translational significance are also identified across disease types, as well as the future potential of chromatin signaling research.

Zielgruppe

<p>translational researchers, clinicians and graduate students in genomic medicine, epigenetics, neurology, neuroscience, and neuropsychiatry interested in genetics and epigenetic basis of neurological disorders; life science researchers; developmental biologists; neurologists, psychiatrists, and other MD/clinicians; pharmacologists in industry and academia</p>

Autoren/Hrsg.

Weitere Mitwirkende

Binda, Olivier

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Naturwissenschaften Biowissenschaften Biowissenschaften DNA und Transgene Organismen

Inhaltsverzeichnis

1. Chromatin and epigenetic signaling pathways 2. Non-pathologic neurological development 3. Spinal muscular atrophy 4. Triplet-Repeat Neurological Diseases 5. Amyotrophic Lateral Sclerosis 6. Charcot-Marie-Tooth disease 7. Parkinson's disease 8. Huntington's disease 9. Multiple Sclerosis 10. Ataxia Telangiectasia 11. Cockayne Syndrome neurodevelopmental disorders 12. Angelman Syndrome and Prader-Willi Syndrome 13. Rett Syndrome 14. Rubinstein-Taybi Syndrome 15. Sotos Syndrome 16. ATRX 17. Fragile X syndrome and mental retardation 18. Autism Spectrum Disorder and Asperger Syndrome 19. Schizophrenia 20. Gilles de la Tourette Syndrome 21. Alzheimer's disease (and other dementias) 22. Mood disorders 23. Attention deficit hyperactivity disorder (ADHD) 24. Obsessive compulsive disorder (OCD)

Über Autor(innen)

Binda, Olivier
Dr. Olivier Binda is a Researcher at the University of Ottawa, specializing in epigenetics and gene expression as it relates to human diseases. Dr. Binda co-edited Chromatin Signaling and Diseases (Elsevier 2016), a volume in Elsevier's Translational Epigenetics series, and has published 20 scientific papers in such peer reviewed journals as the Molecular Cell, Journal of Biological Chemistry, Biochemistry, Epigenetics, Oncogene, Scientific Reports, and Stem Cell Research. In past positions he has served as a postdoctoral fellow at McGill University and Stanford University, and he completed his PhD in Biochemistry at McGill University in 2007.

Affiliations and expertise

University of Ottawa, Department of Cellular and Molecular Medicine, Ottawa, CANADA.