Chemical Carcinogenesis and Mutagenesis I

Erscheinungsjahr 2012
ISBN: 978-3-642-74775-5
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 94 / 1, 604 Seiten, eBook

Reihe: Handbook of Experimental Pharmacology

I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin Madison. I immediately started to work with the carcinogenic aminoazo dyes un der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABE1H CAVERT, in marriage and we soon commenced a joyous part nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re lated factors.

Zielgruppe

Research

Autoren/Hrsg.

Weitere Mitwirkende

Beland, F.A.

Cain, L.G.

Felton, J.S.

Groopman, J.D.

Grover, P.L.

Hall, M.

Hecht, S.S.

Hemminki, K.

Hoffmann, D.

Kadlubar, F.F.

Knize, M.G.

Knowles, M.A.

Lawley, P.D.

Lijinsky, W.

Ludlum, D.B.

Margison, G.P.

O'Connor, P.J.

Phillips, D.H.

Pitot, H.C.

Searle, C.E.

Teale, O.J.

Inhaltsverzeichnis

I. Theories of Carcinogenesis.- 1 Mechanisms of Chemical Carcinogenesis: Theoretical and Experimental Bases.- II. Exposure to Chemical Carcinogens.- 2 Environmental Carcinogens.- 3 Advances in Tobacco Carcinogenesis.- 4 Occupational Carcinogens.- 5 Therapeutic Agents as Potential Carcinogens.- III. In Vivo and In Vitro Carcinogenesis.- 6 In Vivo Testing for Carcinogenicity.- 7 Transformation of Cells in Culture.- IV. Reactions of Carcinogens with DNA.- 8 Metabolic Activation and DNA Adducts of Aromatic Amines and Nitroaromatic Hydrocarbons.- 9 Polycyclic Aromatic Hydrocarbons: Metabolism, Activation and Tumour Initiation.- 10 Interactions of Fungal and Plant Toxins with DNA: Aflatoxins, Sterigmatocystin, Safrole, Cycasin, and Pyrrolizidine Alkaloids.- 11 N-Nitroso Compounds.- 12 Heterocyclic-Amine Mutagens/Carcinogens in Foods.- 13 Modem Methods of DNA Adduct Determination.- 14 Biological Consequences of Reactions with DNA: Role of Specific Lesions.