Cercignani / Dowell / Tofts Quantitative MRI of the Brain

Principles of Physical Measurement, Second edition
2. Auflage 2018
ISBN: 978-1-315-36355-4
Verlag: Taylor & Francis
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 360 Seiten

Reihe: Series in Medical Physics and Biomedical Engineering

Building on the success of the first edition of this book, the winner of the 2004 British Medical Association Radiology Medical Book Competition, Quantitative MRI of the Brain: Principles of Physical Measurement gives a unique view on how to use an MRI machine in a new way. Used as a scientific instrument it can make measurements of a myriad of physical and biological quantities in the human brain and body. For each small tissue voxel, non-invasive information monitors how tissue changes with disease and responds to treatment.

The book opens with a detailed exposition of the principles of good practice in quantification, including fundamental concepts, quality assurance, MR data collection and analysis and improved study statistical power through minimised instrumental variation. There follow chapters on 14 specific groups of quantities: proton density, T1, T2, T2*, diffusion, advanced diffusion, magnetisation transfer, CEST, 1H and multi-nuclear spectroscopy, DCE-MRI, quantitative fMRI, arterial spin-labelling and image analysis, and finally a chapter on the future of quantification. The physical principles behind each quantity are stated, followed by its biological significance. Practical techniques for measurement are given, along with pitfalls and examples of clinical applications.

This second edition of this indispensable 'how to' manual of quantitative MR shows the MRI physicist and research clinician how to implement these techniques on an MRI scanner to understand more about the biological processes in the patient and physiological changes in healthy controls. Although focussed on the brain, most techniques are applicable to characterising tissue in the whole body.

This book is essential reading for anyone who wants to use the gamut of modern quantitative MRI methods to measure the effects of disease, its progression, and its response to treatment.

Autoren/Hrsg.

Cercignani, Mara

Dowell, Nicholas G.

Tofts, Paul S.

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Medizinische Biotechnologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Naturwissenschaften Physik Physik Allgemein

Inhaltsverzeichnis

Concepts: Measurement in MRI

The measurement process: MR data collection and image analysis

Quality assurance:, accuracy, precision, controls and phantoms

Proton density of tissue water

T1: Longitudinal relaxation time

Quantitative T2 mapping in the brain

T2*: Susceptibility weighted imaging and quantitative susceptibility mapping

D: the diffusion of water (DTI)

Advanced models in diffusion MRI

MT: Magnetisation transfer

Quantitative chemical exchange saturation transfer

1H spectroscopy

Multinuclear MR imaging and spectroscopy

T1-weighted dynamic contrast-enhanced MRI

qfMRI: Quantitative functional and metabolic MRI

ASL: Blood perfusion measurement using Arterial Spin Labelling

Image analysis

The future of qMRI

Appendix 1: Greek alphabet for scientific use

Über Autor(innen)

Professor Mara Cercignani, Chair in Medical Physics at Brighton and Sussex Medical School, University of Sussex.

Dr Nicholas Dowell, Lecturer in Imaging Physics, Brighton and Sussex Medical School, University of Sussex.

Professor Paul Tofts, Emeritus professor, Brighton and Sussex Medical School, University of Sussex.