Cell Volume Regulation

Erscheinungsjahr 2018
ISBN: 978-0-12-815456-4
Verlag: William Andrew Publishing

Buch, Englisch, 514 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 1090 g

Cell Volume Regulation and Fluid Secretion, Volume 81, the latest release in the Current Topics in Membranes series highlights new advances in the field, with this new volume presenting interesting chapters on General principles of cell volume regulation, Cell volume maintenance: water and salt homeostasis, The search for ubiquitous cell volume sensor: the role of plasma membrane and cytoplasmic hydrogel, More than membranes, Cellular and membrane biomechanics of CVR response, Molecular identities of volume-regulatory anion channels, Molecular biology and physiology of volume-regulated anion channel (VRAC), the Role of WNKs in the modulation of intracellular chloride, amongst other topics.

Zielgruppe

Addressed to all specialists in this field.

Autoren/Hrsg.

Weitere Mitwirkende

Delpire, Eric

Rasgado-Flores, Hector

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)

Inhaltsverzeichnis

Section 1. General Principles of Cell Volume Regulation 1. Water Homeostasis and Cell Volume Maintenance and Regulation Eric Delpire and Kenneth B. Gagnon 2. Search for Upstream Cell Volume Sensors: The Role of Plasma Membrane and Cytoplasmic Hydrogel Sergei N. Orlov, Aleksandra Shiyan, Francis Boudreault, Olga Ponomarchuk, and Ryszard Grygorczyk 3. Cytoskeletal Contribution to Cell Stiffness Due to Osmotic Swelling; Extending the Donnan Equilibrium Pei-Chuan Chao, Mettupalayam Sivaselvan, and Frederick Sachs 4. Membrane Stiffening in Osmotic Swelling: Analysis of Membrane Tension and Elastic Modulus Manuela A.A. Ayee and Irena Levitan 5. Molecular Identities and ATP Release Activities of Two Types of Volume-Regulatory Anion Channels, VSOR and Maxi-Cl Yasunobu Okada, Toshiaki Okada, Md. Rafiqul Islam, and Ravshan Z. Sabirov 6. Molecular Biology and Physiology of LRRC8 Volume-Regulated Anion Channel (VRAC) James Osei-Owusu, Junhua Yang, Maria del Carmen Vitery, and Zhaozhu Qiu

Section 2. Regulation of Intracellular Chloride and Water Homeostasis 7. Role of WNK Kinases in the Modulation of Cell Volume Paola de los Heros, Diana Pacheco-Alvarez, and Gerardo Gamba 8. Intracellular Macromolecules in Cell Volume Control and Methods of Their Quantification Michael A. Model M.A. and Jonathan C. Petruccelli

Section 3. Cell Volume Regulation in the Airways 9. Slippery When Wet: Airway Surface Liquid Homeostasis and Mucus Hydration Megan J. Webster and Robert Tarran 10. Physiology of the Gut: Experimental Models for Investigating Intestinal Fluid and Electrolyte Transport Isha Dey and Neil A. Bradbury

Section 4. Cell Volume Regulation in the Brain 11. Cell Volume Control in Healthy Brain and Neuropathologies Corinne S. Wilson and Alexander A. Mongin 12. Cytotoxic Swelling of Sick Excitable Cells - Impaired Ion Omeostasis and Membrane Tension Homeostasis in Muscle and Neuron Catherine E. Morris

Über Autor(innen)

Rasgado-Flores, Hector
Dr. Hector Rasgado-Flores teaches at Rosalind Franklin University, Chicago, USA

Delpire, Eric
Eric Delpire, PhD, is a Professor of Anesthesiology and Molecular Physiology and Biophysics in the Department of Anesthesiology at Vanderbilt University Medical Center in Nashville, TN. He earned his PhD in Physiology from the University of Liège, Belgium. He completed postdoctoral training at Wright State University in Dayton, OH, and at Brigham and Women's Hospital in Boston, MA. He is a recognized expert in cell volume regulation and ion transport mechanisms across biological membranes. He is credited with discovering the regulatory pathway involving WNK and SPAK/OSR1 kinases, as well as their interaction with cation-chloride cotransporters. Dr. Delpire has developed numerous genetically modified mouse models of cation-chloride transporters, kinases, and other regulatory molecules, including traditional global and conditional knockouts and knock-ins, as well as CRISPR/Cas9-generated knockout and knock-in models. These models are crucial tools for understanding how genetic mutations in these proteins affect various cellular functions and medical conditions such as hypertension, neurological disorders, and gastrointestinal diseases. For his groundbreaking research, Dr. Delpire has received numerous awards, including the Hugh Davson Distinguished Lectureship (2023) from the Cell and Molecular Physiology Section of the American Physiological Society. He has been elected a fellow of the American Association for the Advancement of Science and the American Physiological Society. He has published over 230 peer-reviewed papers and several book chapters.