Ceelen / Levine Intraperitoneal Cancer Therapy

Principles and Practice
1. Auflage 2015
ISBN: 978-1-4822-6119-6
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 423 Seiten

Encompassing basic principles, clinical results and applications, and future prospects, this comprehensive and timely book on intraperitoneal cancer therapy draws on the expertise of internationally renowned surgical oncologists. Broadly aimed at basic and clinical researchers and practitioners in the field of oncology, it represents the definitive multidisciplinary reference in intraperitoneal cancer therapy. It covers basic concepts such as anatomy, physiology, mathematical models of drug transport as well as practical clinical applications, results from clinical trials, and promising novel preclinical developments.

Autoren/Hrsg.

Ceelen, Wim P.

Levine, Edward

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Gynäkologie, Geburtshilfe
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Chirurgie

Inhaltsverzeichnis

The peritoneum: embryology, anatomy and physiology. Embryology and anatomy of the peritoneal cavity. Structure and function of the mesothelial cell. Applied (radiological) anatomy. Peritoneal drug transport. Peritoneal carcinomatosis: basic mechanisms. Molecular biology of peritoneal carcinomatosis. Dissemination and adhesion of peritoneal cancer cells to the peritoneal wall. Genomic approaches to peritoneal carcinomatosis. Surgery, wound healing, and peritoneal minimal residual disease in colorectal cancer. The role of the greater omentum in the pathogenesis of peritoneal carcinomatosis. Lymphatic transport and the diaphragmatic stomata. Intraperitoneal drug therapy: basic principles. Pharmacokinetics of intraperitoneal cytotoxic drug therapy. Tissue transport and pharmacodynamic aspects of intraperitoneal chemotherapy. Mathematical models of intraperitoneal drug delivery. Surgical techniques for intraperitoneal drug delivery. Management of peritoneal metastases using cytoreductive surgery and perioperative chemotherapy. Chemoperfusion techniques and technology. Port placement for intraperitoneal chemotherapy. Clinical results of intraperitoneal drug delivery. Ovarian cancer: initial chemotherapy. Cytoreductive surgery and HIPEC in the treatment of advanced epithelial ovarian cancer and serous papillary peritoneal carcinoma. Pseudomyxoma peritonei. Colorectal cancer. Diffuse malignant peritoneal mesothelioma: current concepts in evaluation and management. Gastric cancer and intraperitoneal chemotherapy. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma. Peritoneal surface malignancy for neuroendocrine tumors. High-grade appendiceal cancer. Systemic therapy for appendiceal cancer. Toxicity and morbidity of intraperitoneal drug delivery. Safety considerations - occupational hazards. Intraperitoneal therapy for palliation of ascites. Novel and experimental approaches. Development of drug-loaded particles for intraperitoneal therapy. Biomaterials and drug delivery systems for intraperitoneal chemotherapy. Intraperitoneal non-viral nucleic acid delivery in the treatment of peritoneal cancer. Immunotherapy of peritoneal carcinomatosis. Oncolytic virus-based intraperitoneal therapy. Pressurized intraperitoneal aerosol chemotherapy.