Biological Effects of Low Level Exposures to Chemical and Radiation

1. Auflage 2019
ISBN: 978-1-138-55774-1
Verlag: CRC Press

Buch, Englisch, 172 Seiten, Format (B × H): 156 mm x 234 mm, Gewicht: 272 g

Reihe: CRC Press Revivals

This book features papers presented at a workshop discussing current knowledge about the biological effects of low level exposures (BELLE). The book is designed to help establish a scientific base for future BELLE initiatives and is focused on the issue of the toxicological implications of biological adaptations. Hormesis is considered in a broad, conceptual manner, as well as at molecular and biochemical levels. Other topics covered include the effects of low levels of radiation on biological systems, how the liver adapts to genetic insults, biostatistical considerations when designing studies that address issues associated with biological responses to low doses of chemicals and radiation, and the issues that surround the interpretation of findings from such studies.

Autoren/Hrsg.

Calabrese, Edward J.

Fachgebiete

• Naturwissenschaften Chemie Chemie Allgemein
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

1.Hypotheses on Mammalian Aging, Toxicity, and Longevity Hormones 2. The Role of the ‘Stress Protein Response’ in Hormesis 3. DNA Repair 4. Biochemical Mechanisms of Biphasic Dose-Response Relationships 5. Effects of Low-Dose Radiation on the Immune Reponse 6. Cellular Adaption as an Important Response During Chemical Carcinogenesis 7. Bio statistical Approaches for Modelling U-shaped Dose-Response Curves and Study Design Considerations in Assessing the Biological Effects of Low Doses

Über Autor(innen)

Edward J. Calabrese is an American toxicologist and professor in the department of environmental health sciences at the University of Massachusetts Amherst. He is the editor-in-chief of the scientific journal Dose-Response.