Burgess Solid-Phase Organic Synthesis

1. Auflage 2004
ISBN: 978-0-471-45845-6
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 296 Seiten, E-Book

Solid-Phase Organic Synthesis Edited by KevinBurgess, Texas A & M University Efficient, high-throughputchemistry is now the focus of many research laboratories.Solid-phase organic syntheses are central to many of thesecombinatorial and parallel screening methodologies. Consequently,they have been a major scientific theme of the 1990s and promise toremain prominent for the first part of the new millennium. Indeed,a bewildering number of papers have entered the literature on thistopic; some report minor modifications enabling transformation ofsolution-phase methods to a solid support, while others reportmajor innovations. Solid-Phase Organic Synthesis collects,highlights, and critiques some of the key developments in thefield.
Leading practitioners explain different perspectives on diverseaspects of the area. Specific topics covered include:
* Syntheses of guanidines
* Palladium-catalyzed C-C bond forming reactions
* S_nAr reactions for the formation of heterocycles
* Sequence-specific arylalkyne oligomers
* Resin-supported capture agents and other reagents
* Synthesis on pins
* Monitoring of supported reactions using IR
* Solid-phase syntheses of natural product derivatives
Of related interest: Combinatorial Chemistry andMolecular Diversity in Drug Discovery, Eric M. Gordon and JamesF. Kerwin 1998 (0-471-15518-7) 544 pp. Combinatorial ChemistrySynthesis and Application, Stephen R. Wilson and Anthony W.Czarnik 1997 (0-471-12687-X) 288 pp.

Autoren/Hrsg.

Burgess, Kevin

Inhaltsverzeichnis

Solid Phase Syntheses of Guanidines (K. Burgess & J.Chen).
Palladium-catalyzed Carbon-carbon Bond Formation on Solid Supports(M. Todd & C. Abell).
Benzofused Heterocycles via Solid-phase S_NAr Reactions (M. Schwarz& M. Gallop).
Solid-phase Synthesis of Sequence-specific PhenylacetyleneOligomers (J. Moore, et al.).
Polymer-assisted Solution Phase Methods for Chemical LibrarySynthesis (D. Flynn, et al.).
Solid-phase Organic Synthesis on Radiation-grafted PolymerSurfaces: Application of SynPhase(TM) Crowns to Multiple ParallelSyntheses (I. James, et al.).
Vibrational Spectroscopy for Optimization of Solid-phase OrganicSyntheses (B. Yan).
Recent Advances in Solid-phase Synthesis of Natural Products (L.Wilson).