E-Book, Englisch, 246 Seiten
Bürkle Poly(ADP-Ribosyl)ation
1. Auflage 2008
ISBN: 978-0-387-36005-8
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark
E-Book, Englisch, 246 Seiten
Reihe: Molecular Biology Intelligence Unit
ISBN: 978-0-387-36005-8
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark
This is the most comprehensive, up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage, Parkinson's disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions. Richly illustrated, it offers 19 chapters written by international experts.
Autoren/Hrsg.
Weitere Infos & Material
1;Contents;5
2;Editor;10
3;Preface;15
4;Chapter 1 Enzymes in Poly(ADP-Ribose) Metabolism;16
5;Chapter 2 PARP-2: Structure-Function Relationship;28
6;Chapter 3 Targeting the Poly(ADP-Ribose) Glycohydrolase (PARG) Gene in Mammals;47
7;Chapter 4 DNA Damage Signaling through Poly(ADP-Ribose);56
8;Chapter 5 Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and in the Maintenance of Neuronal Integrity;66
9;Chapter 6 Functional Interactions of PARP-1 with p53;76
10;Chapter 7 Dynamic Interaction PCNA and p21 wafl/apl between PARP-1,;82
11;Chapter 8 PARP-1 as Novel Coactivator of NF-gB in Inflammatory Disorders;90
12;Chapter 9 PARP and Epigenetic Regulation;106
13;Chapter 10 PARP and the Release of Apoptosis-Inducing Factor from Mitochondria;118
14;Chapter 11 Genome Degradation by DNAS1L3 Endonuclease: A Key PARP-1-Regulated Event in optosis;133
15;Chapter 12 NAD: Metabolism and Regulatory Functions;147
16;Chapter 13 PARP-1 and the Shape of Cell Death;156
17;Chapter 14 P01y(ADP-Rib0se) Polymerase (PARP) and Excitotoxicity;168
18;Chapter 15 Poly(ADP-Ribose) Polymerase and Ischemia-Reperfusi0n Injury;179
19;Chapter 16 Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Inflammation and Circulatory Shock;199
20;Chapter 17 Role of Poly-ADP-Ribosylati0n in Cancer Development;218
21;Chapter 18 PARP Inhibitors and Cancer Therapy;233
22;Chapter 19 Poly(ADP-Ribosyl)ation and Aging;249
23;Index;257




