Bradshaw / Spilker Quantitative Systems Pharmacology

1. Auflage 2025
ISBN: 978-3-032-02692-7
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 354 Seiten

Reihe: Handbook of Experimental Pharmacology

Quantitative Systems Pharmacology as a discipline has matured over the past decade and is being used more frequently in academia and industry; however, dedicated training programs and courses are limited. This book will provide a go-to educational reference for a broad audience with topics including: the technology’s history, comparisons to other modeling methods and emerging opportunities to bring methods together, best practice for implementation illustrated by real-world examples, and finally a summary of where the technology is headed in the future.

Zielgruppe

Research

Autoren/Hrsg.

Bradshaw, Erica L.

Spilker, Mary E.

Inhaltsverzeichnis

Part 1 Fundamental Modeling.- What Is QSP and Why Does It Exist A Brief History.- Breadth of Pharmacology Modeling Fundamentals of Pharmacokinetics, Pharmacodynamics, and Mechanistic Modeling.- A Framework for Quantitative Systems Pharmacology Model Execution.- Role of data in development and application of Quantitative Systems Pharmacology models.- Integrating QSP and ML to Facilitate Drug Development and Personalized Medicine.- Part 2 Model Development and Application.- Quantitative Systems Pharmacology Development and Application in Neuroscience.- Quantitative Systems Pharmacology Modeling in Immuno Oncology Hypothesis Testing, Dose Optimization, and Efficacy Prediction.- Application of Mechanistic Mathematical Modeling to Toxicology Quantitative Systems Toxicology (QST).- The Role of Cross Institutional and Interdisciplinary Collaboration in Defining and Executing a Quantitative Systems Pharmacology Strategy.- Part 3 Current Challenges and Future Direction.- Future Directions for Quantitative Systems Pharmacology.