Pharmaceutical Crystallography

A Guide to Structure and Analysis
Erscheinungsjahr 2019
ISBN: 978-1-78262-966-5
Verlag: RSC Publishing

Buch, Englisch, 304 Seiten, Format (B × H): 161 mm x 241 mm, Gewicht: 614 g

The pharmaceutical industry has become acutely aware of the importance of the solid state, but pharmaceutical scientists often lack specific training in topics related to solid-state structure and crystallography. This book provides needed support in this topical area.

Taking an intuitive and informal approach to solid-state structure and crystallographic concepts, this book is written for anyone who needs a clear understanding of modern crystallography, with specific reference to small-molecule pharmaceutical solids. The author describes molecular crystals and crystal structures, symmetry, space groups, single-crystal and powder X-ray diffraction techniques and the analysis and interpretation of crystallographic data. Useful technical details are presented where necessary and case studies from the pharmaceutical literature put theory into a practical context.

Written by an internationally leading figure and with its focus on molecular crystals, this book is equally applicable to chemists with a need to understand and apply X-ray crystal-structure determination.

Autoren/Hrsg.

Bond, Andrew

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Naturwissenschaften Chemie Physikalische Chemie Chemische Kristallographie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

Pharmaceutical Solids;

What Defines a Crystal?;

Symmetry in Crystals;

Space Groups;

Planes and Crystal Morphology;

Crystal Structures and Diffraction Patterns;

Symmetry in Diffraction Patterns;

Single-crystal X-ray Diffraction (Part 1);

Single-crystal X-ray Diffraction (Part 2);

Powder X-ray Diffraction;

Solving X-ray Crystal Structures;

Refining X-ray Crystal Structures;

Disorder and Twinning;

Crystallographic Results