Matrix Metalloproteinases in Tissue Remodelling and Inflammation

2008
ISBN: 978-3-7643-8584-2
Verlag: Springer

Buch, Englisch, 168 Seiten, Format (B × H): 170 mm x 257 mm, Gewicht: 508 g

Reihe: Progress in Inflammation Research

Matrix metalloproteinases (MMPs) are proteolytic enzymes believed to be involved in many physiological and pathological processes associated with inflammatory reactions. MMP synthesis and functions are regulated by three major mechanisms including transcriptional activation, post-transcriptional processing, and control of activity by tissue inhibitors of metalloproteinases (TIMPs). Many cell types have been identified as producers of MMPs and TIMPs in a context of inflammatory processes. MMPs are involved in numerous inflammatory diseases, including respiratory, cardiovascular and central nervous system pathologies.

This volume presents new advances in the involvement of MMPs in various diseases associated with inflammatory processes. Moreover, the recent development of selective and non selective inhibitors of MMPs provides new insights in the relationship between activation of inflammatory cells and tissue remodelling and advises new therapeutic possibilities for the treatment of inflammatory diseases.

Zielgruppe

Research

Autoren/Hrsg.

Boichot, Elisabeth

Lagente, Vincent

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Proteinforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Pneumologie, Atmung, Asthma
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Infektionskrankheiten
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie

Inhaltsverzeichnis

The role of MMPs in the inflammatory process of acute lung injury.- Matrix metalloproteinases in airways inflammation of asthma and chronic obstructive pulmonary disease.- Role of matrix metalloproteases in pulmonary fibrosis.- Anti-inflammatory properties of MMP inhibitors in experimental models of chronic obstructive pulmonary disease and lung inflammation.- Role of matrix metalloproteinases (MMPs) in cystic fibrosis.- MMPs, inflammation and pulmonary arterial hypertension.- MMP roles in the initiation and progression of cardiac remodeling leading to congestive heart failure.- Matrix metalloproteinases and inflammatory diseases of the central nervous system.- Extracellular matrix remodelling and matrix metalloproteinases in the liver.