Plant-Based Drug Discovery

Unveiling Molecular Targets for Metabolic Conditions
Erscheinungsjahr 2025
ISBN: 978-0-443-31698-2
Verlag: Elsevier Science

Buch, Englisch, 648 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 450 g

Plant-Based Drug Discovery: Unveiling Molecular Targets for Metabolic Conditions provides an in-depth examination of the molecular mechanisms of phytochemicals and their potential in treating metabolic diseases. This comprehensive guide begins with an introduction to the prevalence and impact of metabolic disorders, emphasizing the significant role of phytochemicals in their management. The book delves into scientific concepts and research findings, offering valuable insights for researchers and healthcare professionals in the fields of molecular biology, biochemistry, pharmacology, and biotechnology. Chapters cover various crucial topics such as oxidative stress, epigenetic mechanisms, and mitophagy.

In addition, they explore the targeting of molecular chaperones and the molecular targets of plant nutraceuticals for treating obesity, cardiovascular disease, and type 2 diabetes. The book also addresses technological advances, including AI and nanotechnology, highlighting opportunities and challenges in improving the use of plant molecules for metabolic disorder treatments. It serves as an essential resource for those engaged in drug discovery and related areas.

Autoren/Hrsg.

Bisht, Mamta

Singh, Ajay

Srivastava, Akhileshwar Kumar

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

Section I: Introduction
1. Overview of lifestyle-related metabolic disorders

Section II: Phytochemicals and molecular targets
2. Significance of phytochemicals in metabolic disorders
3. Exploring the role of phytochemicals in managing metabolic disorders
4. Enhancing understanding of phytochemicals’ role in managing metabolic disorders
5. Molecular connection of oxidative stress and metabolic syndrome: Therapeutic role of phytocomponents
6. Epigenetics mechanisms of phytochemicals in cure of metabolic diseases
7. Unlocking the epigenetic potential: Phytochemicals as agents in the treatment of metabolic diseases
8. Plant-derived bioactive peptides for treatment of metabolic disorders
9. Efficiency of phytochemicals to cure metabolic diseases by targeting mitophagy
10. The Potential of phytochemicals in mitophagy-driven treatment of metabolic diseases
11. Phytochemicals as promising therapeutic approaches for inflammasomes-related metabolic disorders
12. Regulatory Impact of phytochemicals on metabolic diseases by targeting Nrf2-ARE signaling mechanism
13. Targeting molecular chaperones with phytochemicals for drug discovery in metabolic ailment

Section III: Nanotechnology methods
14. Molecular targets of plant nutraceuticals against obesity

Section IV: Clinical study
15. Navigating molecular targets: plant nutraceuticals in the battle against obesity

Section V: Technologies and challenges for plant-based drug discovery
16. Molecular insight to cure cardiovascular diseases through plant compounds
17. Mechanistic insights of important medicinal plant compounds in managing type 2 diabetes mellitus
18. Nanotechnological aspects in the development of phyto-therapeutics against metabolic disorders
19. New opportunities and challenges for improving the druggability of plant product against metabolic disorders
20. Clinical evidences of phytochemicals in cure of metabolic diseases
21. Integration of artificial intelligence with traditional medicine for treating diabetes
22. Integration of high-throughput omics technologies in discovery of phytodrugs to treat metabolic diseases
23. Multitargets drug design for screening of phytochemicals to cure of metabolic disorders
24. New opportunities and challenges for improving the drug ability of plant products against metabolic disorders

Über Autor(innen)

Srivastava, Akhileshwar Kumar
Dr. Akhileshwar Kumar Srivastava works as a Research Associate (ICMR) at CSIR-Central Food Technological Research Institute, Mysore, India. In his 11 years of research, he has published more than 18 research articles in reputed international journals, along with 4 books and 11 book chapters. His research specialization is primarily in the area of pharmacognosy with genetics, metabolomics, bioinformatics, and molecular biology associated with targeting virulent factors of diseases. In addition, he has studied at Augusta University (formerly, Georgia Regents University) in Augusta, GA, USA, on a J-1 Exchange Scholar Visa and at Ben-Gurion University, Israel. He is also a life member fellow in the Indian Science Congress and the Agriculture, Nutrition and Health Academy, UK.

Singh, Ajay
Prof (Dr.) Ajay Singh is currently working as Director SALS and Dean Research & Studies in Uttaranchal University, Dehradun, India. He has more than 20 years (including R&D industrial research) of research experience. He has published more than 70 research articles in reputed journals and several chapters during his research work. More than 5 patents and projects are also credited in his account. He has also written 2 academic books for UG and PG students. He has guided more than 50 students for Project thesis of U.G and P. G. students and awarded more than 5 Ph. D students and several are registered under him. He is the receipt of young Scientist award by Scientific Planet Society India and several other awards.