Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics

1. Auflage. Softcover version of original hardcover Auflage 2004
ISBN: 978-3-642-07375-5
Verlag: Springer

Buch, Englisch, 350 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 552 g

Reihe: Current Topics in Microbiology and Immunology

Negative-strand RNA viruses, so named because of the polarity of their genomic RNA to mRNA, include important human and non-human pathogens. This volume covers major advances in reverse genetics techniques over the past decade, state-of-the-art basic science and the clinical implications of experimental findings. This should rekindle interest in negative-strand RNA viruses among readers, including those in other disciplines, leading to further progress in understanding these important viruses and in developing effective measures of control.

Zielgruppe

Research

Autoren/Hrsg.

Weitere Mitwirkende

Kawaoka, Yoshihiro

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften DNA und Transgene Organismen
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Virologie

Inhaltsverzeichnis

List of Contents.- Reverse Genetics of Mononegavirales.- Reverse Genetics Systems for the Generation of Segmented Negative-Sense RNA Viruses Entirely from Cloned cDNA.- Transcription and Replication of Nonsegmented Negative-Strand RNA Viruses.- Orthomyxovirus Replication, Transcription, and Polyadenylation.- Escaping from the Cell: Assembly and Budding of Negative-Strand RNA Viruses.- Accessory Genes of the Paramyxoviridae, a Large Family of Nonsegmented Negative-Strand RNA Viruses, as a Focus of Active Investigation by Reverse Genetics.- Identification and Characterization of Viral Antagonists of Type I Interferon in Negative-Strand RNA Viruses.- Toward Novel Vaccines and Therapies Based on Negative-Strand RNA Viruses.- Influenza Vaccines Generated by Reverse Genetics.