Advances in Molecular Pathology

1. Auflage 2023
ISBN: 978-3-031-26162-6
Verlag: Springer Nature Switzerland

Buch, Englisch, 330 Seiten, Format (B × H): 183 mm x 260 mm, Gewicht: 852 g

Reihe: Advances in Experimental Medicine and Biology

The present work corresponds to a compilation of independent contributions in the fields of endocrinology, immunity, cancer, neurobiology, and myology. Revision of current advances as well as novel findings in the form of original articles are presented in a balanced fashion. The book has been divided into three sections in line with the main subject: Molecular pathology of immune, inflammatory, and hemostatic disorders; Molecular pathology of endocrine and muscular disorders; and Molecular pathology of cancer: determinants and potential therapies. In the first section, contributing authors take the reader through the molecular pathology of immune responses, inflammation, and hemostasis, by collating an update on systemic autoimmune diseases, the therapeutic potential of statins in hemostasis, the effects of adrenergic stimulation on coagulation, the emerging field of physical burnout due to the mobility restrictions in response to the 2020 SARS-CoV-2 pandemic imposed worldwide, and the success of community-oriented muscular kinesic rehabilitation. The second section presents engaging results from a survey of iodine intake through the diet of pregnant females, an appraisal of the neuroprotective effect of dexmedetomidine, novel evidence on muscle physiopathology, describing the upregulation of CCL5/RANTES during cholestatic liver disease, the fibrotic response emerging in response to cholic and deoxycholic acids, and the altering effects of bile acids in autophagy and mitogenesis. In the third section, a comprehensive revision of cancer literature is offered with an emphasis on melanoma, myeloid-derived suppressor cells, microRNA-based diagnostic approaches, and new avenues for cancer immunotherapy. Altogether, these individual contributions offer a comprehensive and up-to-date outlook of the current state in the field of molecular pathology.

Chapter 14 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Zielgruppe

Research

Autoren/Hrsg.

Bernabeu, Carmelo

Simon, Felipe

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft

Inhaltsverzeichnis

SECTION 1: Molecular pathology of immune, inflammatory, and hemostatic disorders
1. Immune responses at host barriers and their importance in systemic autoimmune diseasesKatina Schinnerling, Hugo A Penny, Jorge A Soto, and Felipe Melo-Gonzalez.
2. Statins and hemostasis: therapeutic potential based on clinical evidenceYolanda Prado, Diego Aravena, Felipe M. Llancalahuen, Cristóbal Aravena, Felipe Eltit, Cesar Echeverria, Sebastian Gatica, Claudia A Riedel, and Felipe Simon.
3. Effects of adrenergic receptor stimulation on human hemostasis: A systematic reviewSebastian Gatica, Diego Aravena, Cesar Echeverria, Juan F Santibanez, Claudia A Riedel, and Felipe Simon.
4. a1-adrenergic stimulation increases platelet adhesion to endothelial cells mediated by TRPC6Felipe M. Llancalahuen, Alejando Vallejos, Diego Aravena, Yolanda Prado, Sebastian Gatica, Carolina Otero, and Felipe Simon.
5. Physical Activity, Burnout, and Engagement in Latin American Students of Higher Education during the COVID-19 PandemicAndrea Gonzalez, Oscar Achiardi, Martina Valencia, and Claudio Cabello-Verrugio.
6. Small plastics, big inflammatory problemsYolanda Prado, Cristóbal Aravena, Diego Aravena, Felipe Eltit, Sebastian Gatica, Claudia A. Riedel, and Felipe Simon.
7. Impact of a community-based pelvic floor kinesic rehabilitation program on the quality of life of Chilean adult women with urinary incontinenceEduardo Cifuentes-Silva, Natalia Valenzuela-Duarte, Ismael Canales-Gajardo, and Claudio Cabello-Verrugio.
SECTION 2: Molecular pathology of endocrine and muscular disorders
1. Iodine intake based on a survey from a cohort of women at their third trimester of pregnancy from the Bosque County ChileMaría Cecilia Opazo, Camilo Fuentes Pena C, Luis Méndez, Diana Rojas, Daniel Aguayo, Juan Carlos Oyanedel, Rodrigo Moreno-Reyes, Nelson Wolhk, Alexis M. Kalergis, and Claudia A. Riedel.
2. Appraisal of the neuroprotective effect of dexmedetomidine: a meta-analysisSebastian Gatica, Cristobal Aravena, Yolanda Prado, Diego Aravena, Cesar Echeverria, Juan F Santibanez, Claudia A Riedel, and Felipe Simon.
3. Bile acids alter the autophagy and mitogenesis in skeletal muscle cellsFranco Tacchi, Josué Orozco-Aguilar, Mayalen Valero-Breton, and Claudio Cabello-Verrugio.
4.Upregulation of CCL5/RANTES gene expression in the diaphragm of mice with cholestatic liver diseaseVania Morales, Andrea González, and Claudio Cabello-Verrugio.
5. Differential fibrotic response of muscle fibroblasts, myoblasts, and myotubes to cholic and deoxycholic acidsLuis Maldonado, Josué Orozco-Aguilar, MayalenValero-Breton, Franco Tacchi, Eduardo Cifuentes-Silva, and Claudio Cabello-Verrugio.
6. BMAL1 regulates glucokinase expression through E-box elements in vitroPaula Llanos, Patricio Ordenes, David B. Rhoads, Juan F. Santibanez, María García-Robles, and Carola Millán.
SECTION 3: Molecular pathology of cancer: determinants and potential therapies
1. Correlation between endoglin and malignant phenotype in human melanoma cells: analysis of hsa-mir-214 and hsa-mir-370 in cells and their extracellular vesiclesLidia Ruiz-Llorente, María Jesús Ruiz-Rodríguez, Claudia Savini, Teresa González-Muñoz, Erica Riveiro-Falkenbach, José L. Rodríguez-Peralto, Héctor Peinado, and Carmelo Bernabeu.
2. Increase in Frequency of Myeloid-Derived Suppressor Cells in the Bone Marrow of Myeloproliferative Neoplasm: Potential Implications in MyelofibrosisSuncica Kapor, Sanja Momcilovic, Slobodan Kapor, Slavko Mojsilovic, Milica Radojkovic, Milica Apostolovic, Branka Filipovic, Mirjana Gotic, Vladan Cokic, and Juan F Santibanez.
3. The “Ins and Outs” of prostate specific membrane antigen (PSMA) as specific target in prostate cancer therapyFelipe Eltit, Nicole Robinson, Pak Lok Ivan Yu, Mitali Pandey, Jerome Lozada, Yubin Guo, Manju Sharma, Dogancan Ozturan, Laetitia Ganier, Eric Belanger, Nathan A. Lack, David M. Perrin, Michael E. Cox, and S. Larry Goldenberg.
4. Transforming Growth Factor-ß1 in Cancer Immunology: opportunities for immunotherapyVíctor H. Villar, Tijana Suboticki, Dragoslava Ðikic, Olivera Mitrovic Ajtic, Felipe Simon, and Juan F. Santibanez.

Über Autor(innen)

Felipe Simon, Ph.D., is currently Full Professor of the Faculty of Life Sciences in Universidad Andres Bello, at Santiago, Chile, and Researcher at the Millennium Institute of Immunology and Immunotherapy. His line of research is mainly focused on understanding the molecular mechanisms involved in systemic inflammatory syndromes, with a special interest in vascular and immune dysfunction, to identify suitable molecular targets and develop new and more efficient therapies to tackle organ damage and mortality. He has published more than 100 articles with more than 3,800 citations and has an H-index=40 (Google Scholar, 2022). He has been conferred several awards, participated as Expert Evaluator in numerous accreditation committees, and is currently Director of Research of the Faculty of Life Sciences at Universidad Andres Bello. He is Member of Chilean Society of Physiological Science and the American Physiological Society.Carmelo Bernabeu, Ph.D., is Research Professor at the Spanish National Research Council since 2003. His scientific interest focuses on cardiovascular diseases involving endoglin, a cell surface receptor present in endothelial cells. Among them are: hereditary hemorrhagic telangiectasia (HHT), a vascular disease caused by heterozygous mutations in the endoglin gene; and preeclampsia, a disease affecting pregnant women and associated with hypertension and proteinuria, in which a pathogenic role has been described for elevated levels of a circulating form of endoglin. He has worked in different US universities and research centers, including the University of California at Los Angeles, Harvard University Medical School in Boston, and University of Utah in Salt Lake City. He has published more than 200 articles with more than 18,000 citations and has an H-index=71 (Google Scholar, 2022). He is Editor of several international journals in the area of Biomedicine and is current Member and past Chair of the Global Research and Medical Advisory Board of the Hereditary Hemorrhagic Telangiectasia Foundation.