Buch, Englisch, Band 663, 434 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 680 g
Buch, Englisch, Band 663, 434 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 680 g
Reihe: Advances in Experimental Medicine and Biology
ISBN: 978-1-4614-2545-8
Verlag: Springer
This book describes recent developments concerning structural, functional and possible therapeutic aspects of one particular CAM, the neural cell adhesion molecule (NCAM).
Adhesive interactions are important for cell trafficking, differentiation, function and tissue formation. In the nervous system, many cell adhesion molecules (CAMs) are involved in migration of neuroblasts, outgrowth and fasciculation of neuronal processes, formation of synapses and rearrangements of synaptic contacts associated with plasticity including learning and memory. More than eighty CAMs were found to be localized at synaptic sites, where they in a regulated manner bridge pre- and postsynaptic specializations thereby modulating synaptic function. Structure and Function of the Neural Cell Adhesion Molecule NCAM describes recent developments concerning structural, functional and possible therapeutic aspects of one particular CAM, the neural cell adhesion molecule (NCAM). NCAM is one of the first identified and most studied CAMs, and this book is the first attempt to collectively summarize our current knowledge of this important cell adhesion molecule.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
- Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Physiologie
- Naturwissenschaften Biowissenschaften Biowissenschaften Neurobiologie, Verhaltensbiologie
Weitere Infos & Material
Preface
Structural Biology of NCAM
Vladislav Soroka, Christina Kasper and Flemming M. Poulsen
Extracellular Protein Interactions Mediated by NCAM: Heterophilic Interactions between NCAM and Cell Adhesion Molecules, Extracellular Matrix Proteins, and Viruses
Janne Nielsen, Nikolaj Kulahin and Peter S. Walmod
Intracellular Ligands of NCAM
Bettina Büttner and Rüdiger Horstkorte
NCAM and the FGF receptor
Vladislav V. Kiselyov
The Role of ATP in the Regulation of NCAM Function
Martin V. Hübschmann and Galina Skladchikova
Polysialylation of NCAM
Herbert Hildebrandt, Martina Mühlenhoff and Rita Gerardy-Schahn
Structural Basis for the Polysialylation of NCAM
Karen J. Colley
The Role of PSA-NCAM in Adult Neurogenesis
Eduardo Gascon, Laszlo Vutskits and Jozsef Zoltan Kiss
Use of PSA-NCAM in Repair of the Central Nervous System
Abderrahman El Maarouf and Urs Rutishauser
Signaling Pathways Involved in NCAM-induced Neurite Outgrowth
Dorte Kornerup Ditlevsen and Kateryna Kolkova
Role of Growth-Associated Protein GAP-43 in NCAM-mediated Neurite Outgrowth
Irina Korshunova, Mark Mosevitsky
NCAM and Lipid Rafts
Gro Klitgaard Povlsen and Dorte Kornerup Ditlevsen
NCAM and Epidermal Growth Factor Receptor: Signaling Crosstalk
Gro Klitgaard Povlsen
Biosynthesis of NCAM
Kateryna Kolkova
Soluble NCAM
Thomas Secher
Role of NCAM in Spine Dynamics and Synaptogenesis
Dominique Muller, Pablo Mendez, Mathias De Roo, Paul Klauser, S. Steen and Lorenzo Poglia
NCAM in Long-term Potentiation and Learning
Barbara P. Hartz and Lars Christian B. Rønn
Role of NCAM in Emotion and Learning
Lisa Conboy, Reto Bisaz, Kamila Markram and Carmen Sandi
NCAM in Neuropsychiatric and Neurodegenerative Disorders
Leann H. Brennaman and Patricia F. Maness
NCAM in Cancer: Expression and Mechanisms
Silvia Zecchini and Ugo Cavallaro
NCAM Mimetic Peptides: An Update
Vladimir Berezin and Elisabeth Bock
Synthetic NCAM-derived Ligands of the FGF receptor
Stine Maria Hansen, Shizhong Li, Elisabeth Bock and Vladimir Berezin
Dendritic Spine and Synapse Morphological Alterations Induced by an NCAM Mimetic
Michael Stewart, Victor Popov, Nilolai Medvedev, Paul Gabbott, Nicola Corbett, Igor Kraev and Heather Davies
Fasciclin II: The NCAM Ortholog in Drosophila melanogaster
Lars V. Kristiansen and Michael Hortsch
The Neural Cell Adhesion Molecule NCAM2/OCAM/RNCAM: A Close Relative of NCAM
Nikolaj Kulahin and Peter S. Walmod
Honoring Dr. Elisabeth Bock
Vladimir Berezin
