Placebo Effects in Neurology

Erscheinungsjahr 2025
ISBN: 978-0-443-29884-4
Verlag: Elsevier - Health Sciences Division

Buch, Englisch, 332 Seiten, Format (B × H): 283 mm x 222 mm, Gewicht: 1164 g

Reihe: Handbook of Clinical Neurology

Placebo Effects in Neurology delves into the intriguing phenomenon of placebos and their profound impact on neurological disorders. This book explores how placebo effects, occurring both in clinical trials and real-world practice, influence therapeutic outcomes, doctor-patient relationships, and symptom perception. The content provides insights into psychobiological mechanisms and specific conditions such as Parkinson’s disease and migraine while addressing ethical and methodological concerns. With discussions on both deceptive and open-label placebos, the book invites readers to reconsider the potential of this underappreciated tool in neurology, offering a bridge between scientific research and practical application in the treatment of various conditions.

Beyond its focus on placebo mechanisms, the book examines their role in alleviating symptoms of neuropathic pain, peripheral neuropathies, fatigue, and neuropsychiatric disorders like depression and anxiety. It also presents a methodological lens on how placebos are used to validate treatments in trials while debating their ethical implications. By weaving together science, ethics, and practical insights, Placebo Effects in Neurology stands out as a compelling resource for clinicians, researchers, and anyone interested in the nuanced intersection of psychology and neurology.

Autoren/Hrsg.

Benedetti, Fabrizio

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

Section I. GENERAL CONSIDERATIONS
1. A brief history of placebo
2. Placebo effects and emotion regulation: Conceptual and neural similarities and differences
3. Understanding the psychology of the nocebo effect
4. Open-label nondeceptive placebos
5. Social aspects
6. Age and gender
7. Conditioned Immune Responses and the neural-immune connection in animals and humans
8. The Role of Mindsets in Placebo Effects and Healthcare
9. The Placebome

Section II. SPECIFIC NEUROLOGIC CONDITIONS
10. Pain
11. The motor system and motor disorders
12. Peripheral neuropathies
13. Placebo and Nocebo Effects in Headaches
14. Placebo Effects in Mental Disorders
15. Miscellaneous neurological conditions with a few or no available data
16. Hypoxia
17. The Placebo Effect in Psychotherapy
18. Interventional procedures and physical therapies
19. The COVID-19 Pandemic: A Special Case of Placebo and Nocebo Effects

Section III. METHODOLOGICAL AND ETHICAL ISSUES
20. Minimizing placebo effects in clinical trials
21. Ethical considerations with using placebo treatments and effects in clinical practice
22. Placebo and the doctor-patient interaction and communication

Über Autor(innen)

Benedetti, Fabrizio
Prof. Fabrizio Benedetti, MD is Professor of Neurophysiology and Human Physiology at the University of Turin Medical School, Italy, and Director of Medicine and Physiology of Hypoxia at Plateau Rosà, Switzerland. He identified the basic mechanisms of placebo and nocebo effects across a number of medical conditions and therapeutic interventions, including pain, Parkinson’s disease, the endocrine system and oxygen-dependent critical life functions. He has been a consultant and advisor at NIH, NIMH, NIDA, NCCAM and at Harvard University since 2000. He is recipient of the 2009 Medical Book Award of the BMA, the 2012 Seymour Solomon Award of the American Headache Society, and the 2015 William S Kroger Award of Behavioral Medicine from the American Society of Clinical Hypnosis. In 2023 he received the Lifetime Achievement Award of the Society for Interdisciplinary Placebo Studies. He is currently on the editorial boards for Current Neuropharmacology and Canadian Jrnl of Pain.