DNA Topology

2. Auflage 2005
ISBN: 978-0-19-850655-3
Verlag: OUP Oxford

Buch, Englisch, 216 Seiten, Format (B × H): 156 mm x 234 mm, Gewicht: 342 g

DNA as the genetic material is a topic of intense interest in the 21st century, with the genomes of many organisms having been sequenced. The double helix structure discovered by Watson and Crick 50 years ago is now very familiar and its importance for DNA function is widely appreciated. However, it has become clear that there are many deviations from this basic structure that have important biological consequences. Prominent among these are the 'topological' configurations: supercoiling, knotting, and catenation (linking). Unfortunately, a full understanding of these features of DNA structure requires the grasp of concepts that can prove difficult for both students and more advanced researchers. This book aims to explain these ideas simply, but rigorously, to allow a wider appreciation of DNA topology.

DNA Topology starts with a basic account of DNA structure before going on to cover DNA supercoiling, the definitions and physical meanings of linking number, twist, and writhe, and the free energy associated with supercoiling. It then considers the rather more complex description of DNA lying on a curved surface and its application to the nucleosome, followed by the phenomena of DNA knotting and catenation. The final chapters deal with the topoisomerases, the enzymes that control DNA topology, and, most importantly, with the biological significance of the topological aspects of DNA structure. Although some of these concepts are quite complex, they are presented in an accessible way, drawing on interesting and relevant examples.

Zielgruppe

Students and researchers of DNA topology, molecular biology, biochemistry and genetics.

Autoren/Hrsg.

Bates, Andrew D.

Maxwell, Tony

Maxwell, Anthony

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften DNA und Transgene Organismen
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik

Über Autor(innen)

Dr Andy Bates is at the School of Biological Sciences at the University of Liverpool, UK.

Professor Tony Maxwell is Head of the Department of Biological Chemistry at the John Innes Centre, Norwich, UK.