Huntington's Disease

3rd Auflage
ISBN: 978-0-19-851060-4
Verlag: Oxford University Press

Buch, Englisch, 574 Seiten, Format (B × H): 175 mm x 248 mm, Gewicht: 1230 g

It is now almost a decade since the identification of the Huntington's Disease gene and its mutation, during which time, major advances in our understanding of this disorder have been achieved. Since publication of the first two editions of this book, there have been considerable insights into how the mutation leads to the molecular pathology, neuropathology and clinical symptoms of Huntington's Disease, and experimental tools are now in place to take this research further towards new therapeutic approaches. As a result of these major advances, this well-established series of books has required radical updating.

An international group of researchers and clinicians with specialist interests in HD has been commissioned to document the recent advances in our understanding of this disease. Developments in the fields of structural biology, cell biology, neurochemistry and neuropathology, with full coverage of transgenic animal models, are discussed in detail. The clinical sections cover genetic, neurological and psychiatric aspects as well as new developments in therapy.

This book will continue to provide an invaluable source of information for clinicians and scientists involved with Huntington's Disease, including geneticists, psychiatrists and neurologists, and basic science research workers in genetics and neurobiology.

Autoren/Hrsg.

Bates, Gillian

Harper, Peter

Jones, Lesley

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Innere Medizin

Inhaltsverzeichnis

- Section 1 - Clinical aspects of Huntington's disease

- 1: Harper: Huntington's disease: a historical background

- 2: Kremer: Clinical neurology of Huntington's disease

- 3: Craufurd and Snowden: Neuropsychological and neuropsychiatric aspects of Huntington's disease

- 4: Brooks and Andrews: Imaging Huntington's disease

- Section 2 - The genetics of Huntington's disease

- 5: Harper and Jones: Huntington's disease: genetic and molecular studies

- 6: Harper: The epidemiology of Huntington's disease

- 7: Tibben: Genetic counselling and presymptomatic testing

- Section 3 - Neurobiology

- 8: Gutekunst, Norflus and Hersch: The neuropathology of Huntington's disease

- 9: Yohrling and Cha: Neurochemistry of Huntington's disease

- 10: Turner and Schapira: Energy metabolism and Huntington's disease

- Section 4 - Molecular biology and Huntington's disease

- 11: Wanker and Dröge: Structural biology of Huntington's disease

- 12: Jones: The cell biology of Huntington's disease

- 13: Bates and Murphy: Mouse models of Huntington's disease

- Section 5 - Other polyglutamine diseases

- 14: Bates and Benn: The polyglutamine disease

- Section 6 - Therapeutic Interventions

- 15: Nance and Westphal: Comprehensive care in Huntington's disease

- 16: Kieburtz and Shoulson: Therapeutic trials in Huntington's disease

- 17: Dunnett and Rosser: Cell and tissue transplantation