Basu / Wiklund Studies on Experimental Models

2011
ISBN: 978-1-60761-956-7
Verlag: Humana Press
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 698 Seiten, eBook

Reihe: Oxidative Stress in Applied Basic Research and Clinical Practice

There is a widespread consensus that use of antioxidants as a therapeutic approach may counteract free radical mediated pathologies. However, the role of antioxidants in normal physiology and redox signaling is still in its infancy. Since oxidative stress is related to various diseases and pathologies, scientists are eager to study the disease in humans, but it is not always ethical to study all the aspects of the disease in humans. Thus, it becomes mandatory to study the disease process and the mechanisms behind it through experimental models which generally involve animals, in vitro/cell culture studies, primates and even humans to a certain extent. Studies on Experimental Models contains data on the experimental models or review of such models of oxidative stress in various diseases. It is structured into six sections, which are as follows: diabetes, cardiovascular, neurology, ocular diseases, toxicology/environmental and in vitro/tissue culture. Each section presents a sketch of models in humans, animals and in vitro methods. Taken together, they comprise a valuable reference for basic and clinical scientists, one aimed at contributing to the advancement of oxidative stress research using appropriate animal models.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Basu, Samar

Wiklund, Lars

Inhaltsverzeichnis

DIABETES Role of Oxidative Stress and Targeted Antioxidant Therapies in Experimental Models of Diabetic ComplicationsJudy B. de Hann, Karin A. Jandeleit-Dahm, and Terri J. Allen Experimental Models of Oxidative Stress Related to Cardiovascular Diseases and DiabetesMaria Dolores Mesa, Concepcion M. Aguilera, and Angel Gil CARDIOVASCULAR Arachidonic Acid Metabolism and Lipid Peroxidation in Stroke: Alpha-tocotrienol as a Unique Therapeutic AgentCameron Rink, Savita Khanna, and Chandan Sen Assessment of Oxidative Stress in the Brain of Spontaneously Hypertensive Rat and Stroke-Prone Spontaneously Hypertensive Rat Using by Electron Spin Resonance SpectroscopyFumihiko Yoshino, Kyo Kobayashi, and Masaichi-Chang-il Lee Small Heat Shock Proteins and Doxorubicin-induced Oxidative Stress in The HeartKarthikeyan Krishnamurthy, Ragu Kanagasabai, Lawrence J. Druhan, and Govindasamy Ilangovan  Oxidative Stress in Cardiovascular Disease: Potential Biomarkers and Their MeasurementsSubhendu Mukherjee and Dipak K. Das In vivo Imaging of Antioxidant Effects on NF-kappaB Activity in Reporter MiceIngvild Paur, Harald Carlsen, and Rune Blomhoff  NEUROLOGY MPTP and Oxidative Stress: It’s Complicated!V. Jackson-Lewis, C. Vives-Bauza, M.A. Tocilescu, R. DeVries, and S. Przedborski Oxidative Stress in Alzheimer´s Disease: A Critical Appraisal of the Causes and the ConsequencesJaewon chang, Sandra Siedlak, Paula Moreira, Akihiko Nunomura, Rudy J. Castellani, Mark A. Smith, Xiongwei Zhu, George Perry, and Gemma Casadesus Retinal Disturbances in Patients and Animal Models with Huntington’s, Parkinson’s and Alzheimer’s DiseaseC. Santano M. Pérez de Lara Pintor Stress Gene Deregulation in Alzheimer Peripheral Blood Mononuclear CellsOlivier C. Maes, Howard M. Chertkow, Eugenia Wang, and Hyman M. Schipper The Use of Gpx4 Knockout Mice and Transgenic Mice to Study the Roles of Lipid Peroxidation in Diseases and AgingQitao Ran and Hanyu Liang An Experimental Model of Myocardial and Cerebral Global Ischemia and ReperfusionLars Wiklund and Samar Basu  OCULAR DISEASES Neovascular Models of the Rabbit Eye Induced by Lipid HydroperoxideTakako Nakanishi, Toshihiko Udea, Kazushi Tamai, Shinichi Iwai, and Donald Armstrong Purinergic Signaling Involved in the Volume Regulation of Glial Cells in the Rat Retina: Alteration in Experimental DiabetesAndreas Bringmann  TOXICOLOGY / ENVIRONMENTAL  Helicobacter Pylori-induced Oxidative stress and InflammationHyeyoung Kim and Young-Joon Surh Experimental Models for Ionizing Radiation ResearchKristin Fabre, William DeGraff, John A. Cook, Murali C. Krishna, and James B. Mitchell Experimental Models to Study Cigarette Smoke-Induced Oxidative Stress In Vitro and In Vivo in Pre-Clinical Models, and in Smokers and Patients with Airways DiseaseHongwei Yao and Irfan Rahman Exhaled Breath Condensate Biomarkers of Airway Inflammation and Oxidative Stress in COPDPaolo Montuschi Induction of Oxidative Stress by Iron/Ascorbate in Isolated Mitochondria and by UV Irradiation in Human SkinIngrid Wiswedel, Wolfgang Augustin, Sven Quist, Harald Gollnick, and Andreas Gardemann Carbon Tetrachloride Induced Hepatotoxicity: A Classical Model of Lipid Peroxidation and Oxidative StressSamar Basu Enhanced Urinary Excretion of Lipid Metabolites Following Exposer to Structurally Diverse Toxicants: A Unique Experimental Model for the Assessment of Oxidative StressFrancis C. Lau, Manashi Bagchi, Shirley Zafra-Stone and Debasis Bagchi Oxidative Stress in Animal Models with Special Reference to Experimental Porcine EndotoxemiaMiclós Lipcsey, Mats Eriksson, and Samar Basu Models and Approaches for the Study of Reactive Oxygen Species Generation and Activities in Contracting Sketetal MuscleMalcolm Jackson Exercise as a Model to Study Interactions Between Oxidative Stress and InflammationC. Yfanti, S. Nielsen, C Scheele, and B.K. Pedersen Excercise as a  Model to Study Oxidative StressMari Carmen Gomez-Cabrera, Fabian Sanchis-Gomar, Vladimir Essau Martinez-Bello, Sandra Ibanez-Sania, Ana Lunia Nascimento, Li Li Ji, and Jose Vina  IN VITRO/TISSUE CULTURE Models of Mitochondrial Oxidative StressEnrique Cadenas and Alberto Boveris Protection of Oxidant-Induced Neuronal Cells Injury by A Unique Cruciferous NutraceuticalZhenquan Jia, Soumya Saha, Hong Zhu, Yunbo Li, and Hara P. Misra Oxidatively Generated Damage to DNA and Biomarkers Jean Cadet, Thierry Douki, and Jean-Luc Ravanat  Measuring Oxidative Stress in Cell Cultures, Animals and Humans- Analysis and Validation of Oxidatively Damaged DNAHanna L. Karlsson and Lennart Möller The Roles of cAMP and G Protein Signaling in Oxidative Stress-Induced Cardiovascular DysfunctionSoumya Saha, Zhenquan Jia, Dongmin Liu, and Hara P. Misra Cellular and Chemical Assays for Discovery of Novel Antioxidants in Marine OrganismsTim Hofer, Tonje Engevik Eriksen, Espen Hansen, Ingrid Varmedal, Ida-Johanne Jensen, Jeanette Hammer-Andersen, and Ragnar Ludvig Olsen Arsenic-Induced Oxidative Stress: Evidence on In Vitro Models of Cardiovascular, Diabetes Mellitus Type 2 and Neurodegenerative DisordersRubén Ruíz-Ramos, Patricia Ostrosky-Wegman, and Mariano E. Cebrián