Handbook of Statistical Genetics

3. Auflage 2007
ISBN: 978-0-470-05830-5
Verlag: Wiley-Blackwell

Buch, Englisch, 1616 Seiten, Format (B × H): 197 mm x 254 mm, Gewicht: 3248 g

The Handbook for Statistical Genetics is widely regarded as the reference work in the field. However, the field has developed considerably over the past three years. In particular the modeling of genetic networks has advanced considerably via the evolution of microarray analysis. As a consequence the 3rd edition of the handbook contains a much expanded section on Network Modeling, including 5 new chapters covering metabolic networks, graphical modeling and inference and simulation of pedigrees and genealogies. Other chapters new to the 3rd edition include Human Population Genetics, Genome-wide Association Studies, Family-based Association Studies, Pharmacogenetics, Epigenetics, Ethic and Insurance.
As with the second Edition, the Handbook includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between the chapters, tying the different areas together. With heavy use of up-to-date examples, real-life case studies and references to web-based resources, this continues to be must-have reference in a vital area of research.

Edited by the leading international authorities in the field.

David Balding - Department of Epidemiology & Public Health, Imperial College
An advisor for our Probability & Statistics series, Professor Balding is also a previous Wiley author, having written Weight-of-Evidence for Forensic DNA Profiles, as well as having edited the two previous editions of HSG. With over 20 years teaching experience, he's also had dozens of articles published in numerous international journals.
Martin Bishop - Head of the Bioinformatics Division at the HGMP Resource Centre
As well as the first two editions of HSG, Dr Bishop has edited a number of introductory books on the application of informatics to molecular biology and genetics. He is the Associate Editor of the journal Bioinformatics and Managing Editor of Briefings in Bioinformatics.
Chris Cannings - Division of Genomic Medicine, University of Sheffield
With over 40 years teaching in the area, Professor Cannings has published over 100 papers and is on the editorial board of many related journals. Co-editor of the two previous editions of HSG, he also authored a book on this topic.

Autoren/Hrsg.

Balding, David J.

Bishop, Martin

Cannings, Chris

Fachgebiete

• Naturwissenschaften Biowissenschaften Botanik Pflanzenreproduktion, Verbreitung, Genetik
• Mathematik | Informatik Mathematik Stochastik Wahrscheinlichkeitsrechnung
• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Tiergenetik, Reproduktion
• Mathematik | Informatik Mathematik Stochastik Mathematische Statistik
• Naturwissenschaften Biowissenschaften Biowissenschaften DNA und Transgene Organismen
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)

Inhaltsverzeichnis

List of contributors

Editor's Preface to the Third Edition

Glossary of Terms

Abbreviations and Acronyms

Chromosome Maps

Statistical Significance in Biological Sequence

Bayesian Methods in Biological Sequence Analysis

Statistical Approaches in Eukaryotic Gene Prediction

Comparative Genomics

Analysis of Microarray Gene Expression Data

Inferences from microarray data

Bayesian methods for microarray data

eQTL analyses

Protein Structure

Metabonomics

Adaptive Molecular Evolution

Genome Evolution

Probabilistic Models for the Study of Protein Evolution

Application of the Likelihood Function in Phylogenetic

Phylogenetics: Parsimony, Networks and Distances

Evolutionary Quantitative Genetics

Quantitative Trait Loci in Inbred Lines

Mapping Quantitative Trait Loci Outbred Pedigrees

Inferences from Mixed Models in Quantitative Genetics

Marker-Assisted Selection and Introgression

Mathematical Models in Population Genetics

Inference, simulation and enumeration of pedigrees and genealogies

Graphical modelling in genetics

Coalescent Theory

Inference Under the Coalescent

Linkage Disequilibrium, recombination and selection

Inferences from Spatial Population Genetics

Analysis of Population Subdivision

Conservation Genetics

Human population genetics/history

Epidemiology and Genetic Epidemiology

Linkage Analysis

Nonparametric Linkage

Admixture mapping and population structure in association studies

Population Association

Genome-wide association studies

Family-based association studies

Cancer genetics

Epigenetics

Ethics

Insurance

Forensics

Reference Author Index

Subject Index