Bachmann Fibrinolytics and Antifibrinolytics

Erscheinungsjahr 2012
ISBN: 978-3-642-56637-0
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 146, 599 Seiten, eBook

Reihe: Handbook of Experimental Pharmacology

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Bachmann, F.

Inhaltsverzeichnis

Section I: Molecular Biology, Biochemistry, Physiology, and Pharmacology of the Plasminogen-Plasmin Enzyme System.- 1 The Fibrinolytic System and Thrombolytic Agents.- 2 Plasminogen and Streptokinase.- 3 Tissue-type Plasminogen Activator (tPA).- 4 Urinary-type Plasminogen Activator (uPA).- 5 The Inhibitors of the Fibrinolytic System.- 6 Assembly of the Plasminogen System on Cell Surfaces.- Section II: Clinical Use of Thrombolytic Agents.- In Acute Myocardial Infarction.- 7 Streptokinase and Anisoylated Lys-Plasminogen Streptokinase Activator Complex.- 8 Tissue-Type Plasminogen Activator (tPA).- 9 Urokinase and Single-Chain Urokinase-Type Plasminogen Activator (Pro-urokinase).- 10 Comparative Evaluations of tPA vs SK with Particular Reference to the GUSTO-I Trial.- 11 Conjunctive Therapy to Reduce the Occurrence of Coronary Reocclusion After Thrombolytic Treatment of AMI.- Thrombolytic Treatment of other Clinical Thromboembolic Conditions.- 12 New Concepts in Thrombolysis of Pulmonary Embolism.- 13 Deep Venous Thrombosis.- 14 Peripheral Arterial Occlusions.- 15 Thrombotic Cerebrovascular Disease.- Thrombolytic Agents in Development, Biochemistry, Pharmacology — Efficacy in Animal Experiments and First Clinical Trials.- 16 Staphylokinase.- 17 Desmodus rotundus (Common Vampire Bat) Salivary Plasminogen Activator.- 18 Thrombus-Targeting of Plasminogen Activators.- 19 The Hunt for the Ideal Thrombolytic Agent: Mutants of tPA and uPA, Chimera of Both Molecules, Fibrolase.- 20 Agents which Increase Synthesis and Release of Tissue-Type Plasminogen Activator.- Autifibrinolytic Agents.- 21 Structure, Pharmacology, and Clinical Use of Antifibrinolytic Agents.