Drug Development Approaches for Poorly Soluble Compounds

1. Auflage 2026
ISBN: 978-3-527-35478-8
Verlag: Wiley-VCH GmbH

Buch, Englisch, 464 Seiten, Format (B × H): 170 mm x 244 mm

Reihe: Methods and Principles in Medicinal Chemistry

10 different strategies for overcoming poor solubility in drug candidates, drawing on case studies from current drug development projects.

Autoren/Hrsg.

Bachhav, Yogeshwar

Weitere Mitwirkende

Buschmann, Helmut

Holenz, Jörg

Müller, Christa

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie

Inhaltsverzeichnis

1. Drug development approaches for poorly soluble compounds
2. Solid dispersion technique to improve solubility and, thereby, bioavailability
3. Nanosizing of drugs to improve the apparent dissolution and bioavailability
4. Pharmaceutical Co-crystals
5. Self-micro emulsifying and self-emulsifying drug delivery systems to improve solubility and bioavailability
6. Liposomes and mixed micelles for improvement of drug solubility
7. Improvement of solubility and bioavailability of poorly soluble drugs using mesoporous silica particles
8. Gastrointestinal Dissolution and Absorption of BCS Class II Drugs
9. Cyclodextrin-Based Formulations to Improve Solubility of poorly soluble drugs
10. Cosolvent-based formulations to improve solubility and bioavailability
11. First in-animal studies and formulation considerations
12. Improving aqueous solubility of drug candidates through structural modifications
1. Drug development approaches for poorly soluble compounds
2. Solid dispersion technique to improve solubility and, thereby, bioavailability
3. Nanosizing of drugs to improve the apparent dissolution and bioavailability
4. Pharmaceutical Co-crystals
5. Self-micro emulsifying and self-emulsifying drug delivery systems to improve solubility and bioavailability
6. Liposomes and mixed micelles for improvement of drug solubility
7. Improvement of solubility and bioavailability of poorly soluble drugs using mesoporous silica particles
8. Gastrointestinal Dissolution and Absorption of BCS Class II Drugs
9. Cyclodextrin-Based Formulations to Improve Solubility of poorly soluble drugs
10. Cosolvent-based formulations to improve solubility and bioavailability
11. First in-animal studies and formulation considerations
12. Improving aqueous solubility of drug candidates through structural modifications

Über Autor(innen)

Yogeshwar Bachhav is a pharmacist by training and holds a PhD in drug delivery systems from ICT, Mumbai (India). He has worked as research scientist for several years on a collaborative project between Pantec Biosolutions and Geneva University (Switzerland), and as formulation manager at Debiopharm Group, Lausanne (Switzerland). For the last several years he has been associated with AiCuris Anti-infective Cures AG (Germany) as in-charge for Pharmaceutical development of new drugs. In total, he has around 16 years of experience in the preformulation and formulation development of small molecules and peptides for oral, dermal and parenteral application and in drug substance manufacturing.