Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes

1999
ISBN: 978-0-306-46048-7
Verlag: Springer US

Buch, Englisch, Band 303, 294 Seiten, HC runder Rücken kaschiert, Format (B × H): 183 mm x 260 mm, Gewicht: 850 g

Reihe: NATO Science Series A:

The NATO Advanced Study Institute of "Molecular and Applied Aspects of Oxida­ tive Drug Metabolizing Enzymes" was held in Tekirova, Antalya, Turkey, from August 31 to September 11, 1997. This Institute was the third of a series of the NATO ASIs on a similar topic relating to the enzymes of oxidative metabolism of xenobiotics. The first NATO ASI in this series, entitled "Molecular Aspects of Monooxygenases and Bioactiva­ tion of Toxic Compounds" (NATO ASI Series A: Life Sciences, Vol. 202), was held in

Zielgruppe

Research

Autoren/Hrsg.

Arinç, Emel

Hodgson, Ernest

Schenkman, John B.

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

1. The Fate of Xenobiotics in the Body: Enzymes of Metabolism.- 2. Protein-Protein Interactions in the P450 Monooxygenase System.- 3. Structures of Mitochondrial P450 System Proteins.- 4. Biochemical Aspects of Flavin-Containing Monooxygenases (FMOs).- 5. Expression and Regulation of Flavin-Containing Monooxygenases.- 6. Correlations between in Vivo and in Vitro Studies in Human Drug Metabolism.- 7. Pharmacogenetics: Polymorphisms in Xenobiotic Metabolism.- 8. Clinical Aspects of Polymorphic Drug Metabolism in Humans.- 9. Genetic Polymorphisms of Cytochromes P450 1 A1 and 2E1 and of Glutathione S-Transferase M1 and Cancer Susceptibility in the Human.- 10. Cytochrome P450 Isoforms: Insecticide Metabolism in Insects and Mammals and Role in Insecticide Resistance.- 11. Inhibitors of CYP51 as Antifungal Agents and Resistance to Azole Antifungals.- 12. The Role of Oxidative Drug Metabolizing Enzymes in Liver and Lung Specific Toxicity.- 13. Importance of Drug Metabolism in Drug Discovery and Development.- 14. Aflatoxin Biotransformation and Toxicology.- 15. Role of Individual Enzymes in the Control of Genotoxic Metabolites.- 16. Enhancement of the Mutagenicity of Ethylene Oxide and Several Directly Acting Mutagens by Human Erythrocytes and Its Reduction by Xenobiotic Interaction.- 17. Cytochrome P4501 Al (Cyp 1A1) and Associated MFO Activities in Fish as an Indicator of Pollution with Special Reference to Izmir Bay.- 18. Cyp 1A Concentrations as an Indicator of Exposure of Fish to Pulp-Mill Effluents.- 19. The Biochemistry and Physiology of Prostacyclin- and Thromboxane-Synthase.- 20. Cell Engineering of the Rat and Human Cysteine Conjugate Beta Lyase Genes and Applications to Nephrotoxicity Assessment.