Buch, Englisch, 254 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 417 g
Reihe: Contemporary Neuroscience
Ionic Transporters, Pumps, and New Channels
Buch, Englisch, 254 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 417 g
Reihe: Contemporary Neuroscience
ISBN: 978-1-61779-662-3
Verlag: Humana Press
Ischemic brain damage represents a major source of morbidity and mortality in westernized society and poses a significant financial burden on the health care system. To date, few effective therapies have been realized. Recent evidence, however, suggests that channels, pumps, and ionic exchangers are involved in CNS ischemia and ischemic stroke, but the potential contribution of these channels for curing stroke is far less understood than for many other normal and pathological conditions. New Strategies in Stroke Intervention: Ionic Channels, Pumps, and Transporters, analyzes the roles played by targets in stroke development and the potential action of drugs modulating these proteins. This book provides a groundbreaking review of these ionic channels, pumps, and transporters as regulators of neuronal ionic homeostasis, providing a better understanding of ischemic brain disorders and the new pharmacological avenues for a cure.
Zielgruppe
Professional/practitioner
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Kardiologie, Angiologie, Phlebologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
Weitere Infos & Material
Basis of Ionic Dysregulation in Cerebral Ischemia.- Why have Ionotropic and Metabotropic Glutamate Antagonists Failed in Stroke Therapy?.- Mitochondrial Channels as Potential Targets for Pharmacological Strategies in Brain Ischemia.- Endoplasmic Reticulum Calcium Homeostasis and Neuronal Pathophysiology of Stroke.- The Na + /Ca 2+ Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia.- The “Loop” Diuretic Drug Bumetanide-Sensitive Na + -K + -Cl - Cotransporter in Cerebral Ischemia.- The Na + /H + Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia.- The Na + /K + -ATPase as a Drug Target for Ischemic Stroke.- Acid-Sensing Ion Channels (ASICs): New Targets in Stroke Treatment.- Role of TRPM7 in Ischemic CNS Injury.- Subtypes of Voltage-Gated Ca 2+ Channels and Ischemic Brain Injury.- The Diverse Roles of K + Channels in Brain Ischemia.- Clinical Trials with Drugs Targeting Ionic Channels, Antiporters, and Pumps in Ischemic Stroke.
